These goals will be accomplished within the framework of three existing NIH funded projects. The first project, entitled Behavioral Determinants of Opioid/Immune Interactions, provides an examination of Opioid-induced alterations of immune status with emphasis on the role of the central nervous system and pharmacological variables in these interactions. Specifically, the proposal is to conduct studies on the effects of acute and chronic Opioid administration on immune function, and identify the specific brain regions involved in those effects. The second project entitled Immune Alterations Mediated by conditioning, examines how conditioning processes can modulate immune status. This proposal involves examining the role of endogenous opiates in conditioned modulation of immune function. The third project, entitled Opioid-induced alterations of nitric oxide production by peripheral macrophages. This project will determine the subtype(s) of Opioid receptors involved in Opioid-induced alterations of nitric oxide production, and characterize the effect of Opioid administration on nitric oxide production in vivo. Collectively, these projects will provide important new information about Opioid- induced modulation of the immune system, and this award will enhance these investigations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02DA000334-01
Application #
2331131
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Sharp, Charles
Project Start
1997-05-01
Project End
2002-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Mosbruger, Timothy L; Duggal, Priya; Goedert, James J et al. (2010) Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis 201:1371-80
Saurer, Timothy B; Ijames, Stephanie G; Carrigan, Kelly A et al. (2008) Neuroimmune mechanisms of opioid-mediated conditioned immunomodulation. Brain Behav Immun 22:89-97
Szczytkowski, Jennifer L; Lysle, Donald T (2008) Conditioned effects of heroin on proinflammatory mediators require the basolateral amygdala. Eur J Neurosci 28:1867-76