? This application is a competitive renewal of an Independent Scientist Award (K02) to further Dr. Jane Aldrich's research in the area of drug abuse. Dr. Aldrich's long-term goals are to design and use new opioid peptide and peptidomimetic ligands as pharmacological tools to obtain a better understanding of opioid peptide-receptor interactions. The proposed research uses a combination of chemical, pharmacological and computational techniques, with the rationale that the information obtained from these complimentary methodologies will limit the number of possibilities for interactions of the peptides with receptor residues, greatly facilitating the development of models for the peptides bound to opioid receptors. ? ? Continuation of the Independent Scientist Award will allow Dr. Aldrich to expand her expertise in several areas related to her research on opioid peptides. These areas include synthesis (including stereoselective synthesis) of novel amino acid analogs for incorporation into opioid peptide analogs, gaining familiarity with molecular biological techniques to study opioid receptors, and obtaining additional experience with protein characterization by mass spectrometry. Experience in these areas will be synergistic with Dr. Aldrich's expertise in peptide chemistry and significantly enhance her contributions to research in the area of drug abuse. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
2K02DA000393-07
Application #
6726384
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Hillery, Paul
Project Start
1998-09-01
Project End
2009-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
7
Fiscal Year
2004
Total Cost
$129,848
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Fang, Wei-Jie; Bennett, Marco A; Murray, Thomas F et al. (2011) Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 2: effects of substitutions on pharmacological activity. Biopolymers 96:103-10
Fang, Wei-Jie; Bennett, Marco A; Aldrich, Jane V (2011) Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 1: effects of cleavage conditions and N-terminal functionality. Biopolymers 96:97-102
Aldrich, Jane V; McLaughlin, Jay P (2009) Peptide kappa opioid receptor ligands: potential for drug development. AAPS J 11:312-22
Sinha, Bhaswati; Cao, Zhengyu; Murray, Thomas F et al. (2009) Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. J Med Chem 52:7372-5
Patkar, Kshitij A; Murray, Thomas F; Aldrich, Jane V (2009) The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem 52:6814-21
Fang, Wei-Jie; Cui, Yanjun; Murray, Thomas F et al. (2009) Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. J Med Chem 52:5619-25
Aldrich, Jane V; Kumar, Vivek; Murray, Thomas F et al. (2009) Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors. Bioconjug Chem 20:201-4
Aldrich, Jane V; Kumar, Vivek; Dattachowdhury, Bhaswati et al. (2008) Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions. Int J Pept Res Ther 14:315-321