? The overall aim of this proposal is to support the continuing development of the applicant as a research clinician and independent scientist in the field of drug abuse treatment. Three objectives drive the applicant's work: 1) develop pharmacotherapies that consider the heterogeneity of substance abusers 2) provide mentorship to junior clinical investigators, and 3) contribute service to the field. ? ? Although there is a growing literature of various pharmacologic agents for alcohol, opiate or cocaine dependence, there are a limited number of well-controlled trials that have targeted certain psychiatric comorbidities such as ADHD, depression or anxiety disorders. Further, there are scant empirical data regarding targeted pharmacologic interventions for marijuana dependence. During tie proposed K02 competing continuation, the applicant will direct two studies to develop pharmacologic treatment for marijuana dependence. One of the studies will target marijuana withdrawal (P50 09236) and the other study will focus on marijuana-dependent individuals with depression (DA 015451). Extending this approach to other comorbid disorders, the applicant will collaborate with junior investigators who are targeting alcohol dependent individuals with anxiety disorders and schizophrenia. Working with experienced investigators, the applicant plans to 1) better understand the antecedents to alcohol and drug abuse and 2) expand the applicants expertise in utilizing behavioral interventions. Finally, the applicant will continue to contribute to a variety of educational activities at the National and local level, provide ongoing mentorship to young clinical investigators, and offer service to the Substance Abuse field. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA000465-07
Application #
7100975
Study Section
Special Emphasis Panel (ZDA1-MXS-M (07))
Program Officer
Biswas, Jamie
Project Start
2000-08-16
Project End
2010-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
7
Fiscal Year
2006
Total Cost
$122,861
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Levin, Frances R; Mariani, John J; Pavlicova, Martina et al. (2016) Dronabinol and lofexidine for cannabis use disorder: A randomized, double-blind, placebo-controlled trial. Drug Alcohol Depend 159:53-60
Kelly, Meredith A; Pavlicova, Martina; Glass, Andrew et al. (2014) Do withdrawal-like symptoms mediate increased marijuana smoking in individuals treated with venlafaxine-XR? Drug Alcohol Depend 144:42-6
Levin, Frances R; Mariani, John; Brooks, Daniel J et al. (2013) A randomized double-blind, placebo-controlled trial of venlafaxine-extended release for co-occurring cannabis dependence and depressive disorders. Addiction 108:1084-94
Gunderson, Erik W; Levin, Frances R; Rombone, Margaret M et al. (2011) Improving temporal efficiency of outpatient buprenorphine induction. Am J Addict 20:397-404
Mariani, John J; Cheng, Wendy Y; Bisaga, Adam et al. (2011) Comparison of clinical trial recruitment populations: treatment-seeking characteristics of opioid-, cocaine-, and cannabis-using participants. J Subst Abuse Treat 40:426-30
Secora, Alex M; Eddie, David; Wyman, Bertram J et al. (2010) A comparison of psychosocial and cognitive functioning between depressed and non-depressed patients with cannabis dependence. J Addict Dis 29:325-37
Bisaga, Adam; Aharonovich, Efrat; Cheng, Wendy Y et al. (2010) A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period. Drug Alcohol Depend 111:97-104
Gunderson, Erik W; Wang, Xin-Qun; Fiellin, David A et al. (2010) Unobserved versus observed office buprenorphine/naloxone induction: a pilot randomized clinical trial. Addict Behav 35:537-40
Agosti, Vito; Levin, Frances R (2009) Does remission from alcohol and drug use disorders increase the likelihood of smoking cessation among nicotine dependent young adults? Soc Psychiatry Psychiatr Epidemiol 44:120-4
Gunderson, Erik W; Coffin, Phillip O; Chang, Nancy et al. (2009) The interface between substance abuse and chronic pain management in primary care: a curriculum for medical residents. Subst Abus 30:253-60

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