This K02 application seeks support that is essential for the candidate's continued training and career development in substance abuse research. With the support of mentored career awards both from the NIDA and the NIH, the candidate has developed considerable expertise in cognitive and imaging neuroscience. His has shown a record of publication in combining functional magnetic resonance imaging (fMRI) and experimental psychology to delineate the component neural processes of cognitive control, a critical factor contributing to relapse in cocaine dependent patients. He has obtained independent funding to investigate the altered neural processes of cognitive control and how these deficits may predict drug use behavior during follow-up of patients with cocaine dependence. Collaborating with colleagues at the Yale Positron Emission Tomography (PET) Center, he is also proposing to examine the molecular bases in association with altered cognitive control in these patients. Thus, the candidate has proposed a systematic training in (a) advanced data including connectivity analysis of fMRI;(b) PET imaging methodology and procedure;(c) neuropsychopharmacology;(d) clinical treatment outcome and relapse study;and (e) ethics and human subject study training to enhance his knowledge and skills in performing translational and clinical research in substance use disorders. He will acquire the expertise by focusing on three projects during the award period. In the R01 project he will elucidate the neural predictors of relapse in cocaine dependent patients. In the R03 project he will examine these neural processes in the patients with pharmacologically induced cocaine craving. He is also actively seeking funding to examine the regulation of noradrenergic neurotransmission as a molecular basis of """"""""loss of control"""""""" during cocaine craving. Thus, this K02 award is vital for the candidate to receive additional training required to perform the proposed research, to broaden his research scope, and to remain productive in his development into a leading investigator in substance abuse research.

Public Health Relevance

By employing innovative imaging techniques, the candidate seeks to identify the brain processes associated with relapse in cocaine dependent patients. The proposed research will help unravel the etiology and facilitate treatment of this chronic, debilitating mental disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA026990-05
Application #
8513955
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Bjork, James M
Project Start
2009-08-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$127,818
Indirect Cost
$9,468
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mackey, Scott; Allgaier, Nicholas; Chaarani, Bader et al. (2018) Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. Am J Psychiatry :appiajp201817040415
Zhang, Jin-Tao; Ma, Shan-Shan; Li, Chiang-Shan R et al. (2018) Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum. Addict Biol 23:337-346
Ide, Jaime S; Li, Chiang-Shan R (2018) Time scale properties of task and resting-state functional connectivity: Detrended partial cross-correlation analysis. Neuroimage 173:240-248
Liu, Na; Cao, Yuping; Qiao, Huifen et al. (2018) Traumatic Experiences and PTSD Symptoms in the Chinese Male Intrafamilial Physical Violence Perpetrators: A Comparative and Structural Equation Modeling Study. J Interpers Violence :886260518764103
Zhang, Sheng; Hu, Sien; Chao, Herta H et al. (2017) Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study. Brain Struct Funct 222:2573-2583
Li, Chiang-Shan R; Zhang, Sheng; Hung, Chia-Chun et al. (2017) Depression in chronic ketamine users: Sex differences and neural bases. Psychiatry Res Neuroimaging 269:1-8
Chang, Andrew; Ide, Jaime S; Li, Hsin-Hung et al. (2017) Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing. eNeuro 4:
Zhang, Yihe; Ide, Jaime S; Zhang, Sheng et al. (2017) Distinct neural processes support post-success and post-error slowing in the stop signal task. Neuroscience 357:273-284
Cai, Weidong; Chen, Tianwen; Ide, Jaime S et al. (2017) Dissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue. Cereb Cortex 27:4073-4082
Ide, Jaime S; Tung, Hsiang C; Yang, Cheng-Ta et al. (2017) Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field. Front Hum Neurosci 11:222

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