Dr Yiping Han is a PhD microbiologist. Dr Han's research evolves around understanding the virulence mechanism of F. nucleatum. Since joining the faculty at Case Western Reserve University, her research interest has expanded from basic science to include more clinically oriented studies. Dr Han and her colleagues recently developed a pregnant murine model and showed a causal relationship between F. nucleatum and preterm birth. Dr Han is using F. nucleatum as a model organism to investigate the correlation between oral health and preterm birth. She has research support from NIDCR, with an R03 award (DE 14447) to investigate the source of F. nucleatum infection in amniotic fluids in women in preterm labor, and an R01 award (DE 14924) to further characterize the FadA adhesin from this organism. Support from a K02 award will allow Dr Han to forego further grant applications for the near future and to avoid projected increase in teaching and administrative responsibilities. This will permit Dr Han to devote over 80% of her effort on her research program and her plans for re-education in dentistry and reproductive biology. Long term career goals are to become a well-rounded oral microbiologist competent in both basic science and translational research.
The specific aims of this application are: (i) to characterize the FadA adhesin from F. nucleatum for its role in tissue cell attachment and invasion; (ii) to identify the host receptor for FadA and to characterize its role in F. nudeatum-hosl cell interactions; and (iii) to determine if women with amniotic fluid infections of F. nucleatum harbor the same species in the vaginal track, blood, or the oral cavity. ? ? ?

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Scientist Development Award - Research (K02)
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NIDCR Special Grants Review Committee (DSR)
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Hardwick, Kevin S
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Case Western Reserve University
Schools of Dentistry
United States
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Témoin, Stéphanie; Wu, Karen L; Wu, Vivian et al. (2012) Signal peptide of FadA adhesin from Fusobacterium nucleatum plays a novel structural role by modulating the filament's length and width. FEBS Lett 586:1-6
Temoin, Stephanie; Chakaki, Alia; Askari, Ali et al. (2012) Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol 18:117-21
Han, Y W (2011) Oral health and adverse pregnancy outcomes - what's next? J Dent Res 90:289-93
Fardini, Yann; Wang, Xiaowei; Temoin, Stephanie et al. (2011) Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol 82:1468-80
Fardini, Yann; Chung, Peter; Dumm, Rochelle et al. (2010) Transmission of diverse oral bacteria to murine placenta: evidence for the oral microbiome as a potential source of intrauterine infection. Infect Immun 78:1789-96
Han, Yiping W; Fardini, Yann; Chen, Casey et al. (2010) Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol 115:442-5
Han, Yiping W; Shen, Tao; Chung, Peter et al. (2009) Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. J Clin Microbiol 47:38-47
Ortiz, P; Bissada, N F; Palomo, L et al. (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80:535-40
Buhimschi, Catalin S; Bhandari, Vineet; Han, Yiping W et al. (2009) Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Curr Opin Infect Dis 22:235-43
Nithianantham, Stanley; Xu, Minghua; Yamada, Mitsunori et al. (2009) Crystal structure of FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif, the leucine chain. J Biol Chem 284:3865-72

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