Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DK002575-03
Application #
2905009
Study Section
Special Emphasis Panel (SRC)
Program Officer
Hyde, James F
Project Start
1997-09-15
Project End
2002-06-30
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Barnes-Jewish Hospital
Department
Type
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63110
Ponder, Katherine Parker; Melniczek, John R; Xu, Lingfei et al. (2002) Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proc Natl Acad Sci U S A 99:13102-7
Xu, Lingfei; Mango, Robert L; Sands, Mark S et al. (2002) Evaluation of pathological manifestations of disease in mucopolysaccharidosis VII mice after neonatal hepatic gene therapy. Mol Ther 6:745-58
Xu, Lingfei; Haskins, Mark E; Melniczek, John R et al. (2002) Transduction of hepatocytes after neonatal delivery of a Moloney murine leukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs. Mol Ther 5:141-53
Xu, L; Daly, T; Gao, C et al. (2001) CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice. Hum Gene Ther 12:563-73
Gao, C; Kennedy, S; Ponder, K P (2001) Lipopolysaccharide potentiates the effect of hepatocyte growth factor upon replication in lung, thyroid, spleen, and colon in rats in vivo. Mol Ther 3:462-75
Wang, B; Cai, S R; Gao, C et al. (2001) Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4 alpha in rat liver. Hepatology 34:979-89
Gao, C; Sands, M S; Haskins, M E et al. (2000) Delivery of a retroviral vector expressing human beta-glucuronidase to the liver and spleen decreases lysosomal storage in mucopolysaccharidosis VII mice. Mol Ther 2:233-44
Gao, C; Jokerst, R; Gondipalli, P et al. (1999) Lipopolysaccharide potentiates the effect of hepatocyte growth factor on hepatocyte replication in rats by augmenting AP-1 activity. Hepatology 30:1405-16
Gao, C; Jokerst, R; Gondipalli, P et al. (1999) Intramuscular injection of an adenoviral vector expressing hepatocyte growth factor facilitates hepatic transduction with a retroviral vector in mice. Hum Gene Ther 10:911-22