The applicant is seeking a K02 (Independent Scientist Award) to continue building a program of research focusing on the outcomes of childhood traumatic brain injury (TBI). His objectives are (1) to investigate how children's development following TBI is related to severity of injury, age at injury, and time since injury; (2) to examine the role of environmental factors as moderators of recovery from TBI; and (3) to study the relationships between focal brain lesions, cognitive and social problem-solving skills, and """"""""real world"""""""" social functioning following TBI. He has been a Co-Investigator on a prospective, longitudinal study of moderate to severe TBI in school-age children, and currently is Principal Investigator on an NICHD-funded research grant to study the outcomes of mild closed head injuries (CHI) in children and adolescents (see below). His future research efforts will include studies of TBI in preschool children and of the effects of TBI on children's social development. His proposed career development plan will enhance his skills in statistical methods pertinent to his research, including (a) analysis of longitudinal data, (b) treatment of missing data, and (c) robust statistical methods. He also will obtain additional training in the responsible conduct of research.
The specific aims of the research are to examine the (1) natural history, (2) prediction, and (3) consequences of post-concussive symptoms in children with mild CHI. The study will involve 200 8 to 15 year old children with mild CHI and 100 with mild orthopedic injuries not involving the head in a concurrent cohort/prospective research design. The children and their families are assessed four times during the first year post injury (i.e., at 1 week, 1 month, 3 months, and 12 months post-injury). Post-concussive symptoms are assessed using rating scales and interviews, with both children and parents as informants. Predictors of post-concussive symptoms include injury characteristics, cognitive abilities, and non-injury related child and family variables. Outcomes include school performance, health utilization, and other aspects of child and family functioning. The study will examine three major hypotheses: (1) Children with mild CHI display more post-concussive symptoms than children with mild orthopedic injuries. (2) The incidence of post-concussive symptoms is related to (a) injury characteristics, (b) impairments in cognitive skills, and (c) non-injury related child and family factors. (3) Severe post-concussive symptoms are associated with more child disability. The findings will help resolve the scientific controversy regarding the outcomes associated with mild CHI, and will assist physicians and other health care providers in identifying and managing the sequelae of mild CHI. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02HD044099-02
Application #
6719657
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Nitkin, Ralph M
Project Start
2003-04-01
Project End
2008-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
2
Fiscal Year
2004
Total Cost
$105,300
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
147212963
City
Columbus
State
OH
Country
United States
Zip Code
43205
Kingery, Kathleen M; Narad, Megan E; Taylor, H Gerry et al. (2017) Do Children Who Sustain Traumatic Brain Injury in Early Childhood Need and Receive Academic Services 7 Years After Injury? J Dev Behav Pediatr 38:728-735
Taylor, H Gerry; Orchinik, Leah J; Minich, Nori et al. (2015) Symptoms of Persistent Behavior Problems in Children With Mild Traumatic Brain Injury. J Head Trauma Rehabil 30:302-10
Karver, Christine L; Kurowski, Brad; Semple, Erin A et al. (2014) Utilization of behavioral therapy services long-term after traumatic brain injury in young children. Arch Phys Med Rehabil 95:1556-63
McNally, Kelly A; Bangert, Barbara; Dietrich, Ann et al. (2013) Injury versus noninjury factors as predictors of postconcussive symptoms following mild traumatic brain injury in children. Neuropsychology 27:1-12
Fairbanks, Joy M; Brown, Tanya M; Cassedy, Amy et al. (2013) Maternal warm responsiveness and negativity following traumatic brain injury in young children. Rehabil Psychol 58:223-32
Karver, Christine L; Wade, Shari L; Cassedy, Amy et al. (2012) Age at injury and long-term behavior problems after traumatic brain injury in young children. Rehabil Psychol 57:256-65
Fulton, John B; Yeates, Keith Owen; Taylor, H Gerry et al. (2012) Cognitive predictors of academic achievement in young children 1 year after traumatic brain injury. Neuropsychology 26:314-22
Moran, Lisa M; Taylor, H Gerry; Rusin, Jerome et al. (2012) Quality of life in pediatric mild traumatic brain injury and its relationship to postconcussive symptoms. J Pediatr Psychol 37:736-44
Yeates, Keith Owen; Kaizar, Eloise; Rusin, Jerome et al. (2012) Reliable change in postconcussive symptoms and its functional consequences among children with mild traumatic brain injury. Arch Pediatr Adolesc Med 166:615-22
Yeates, Keith Owen; Taylor, H Gerry; Rusin, Jerome et al. (2012) Premorbid child and family functioning as predictors of post-concussive symptoms in children with mild traumatic brain injuries. Int J Dev Neurosci 30:231-7

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