The goal of the five-year career development plan is to establish myself as an independent researcher in the study of cardiac perfusion and mechanical function simultaneously using MRI for improved detection and serial assessment of ischemic heart disease. The ability to differentiate viable and nonviable tissue directly effects clinical reperfusion therapy. Furthermore, the ability to distinguish stunned myocardium from other forms of reversible ischemia, such as hibernation, requires the simultaneous measurement of regional perfusion and function. Most clinical imaging techniques are well-suited to measure either function or perfusion, but not both. In addition, because conventional imaging techniques cannot resolve blood flow or function across the heart wall, inaccurate viability classification due to volume averaging may occur. Cardiac magnetic resonance imaging because of its high spatial resolution, is ideally suited to assess noninvasively both transmural myocardial function (using tagged MRI) and myocardial perfusion (using contrast-enhanced MRI). Thus, the goal of this research is to determine the relationship between compromised myocardial perfusion and mechanical function using novel MRI techniques applied to canine ischemic models. Because the MRI techniques developed in these studies will be readily adaptable to clinical studies, this research could have a significant impact on patient care in ischemic heart disease. The four areas that will be explored during the research project for career development are: 1) training activities to enhance my veterinary skills; 2) tutorials to enhance my skills in cardiac MRI; 3) mentorship by well-known experts in MR, clinical cardiology, and interventional radiology at the Johns Hopkins School of Medicine; and 4) continuing collaborative efforts with leading researchers in the field of cardiovascular medicine to remain abreast of the lastest research developments in areas that intersect with my research interests.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Scientist Development Award - Research (K02)
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Special Emphasis Panel (ZHL1-CSR-K (F2))
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Johns Hopkins University
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United States
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Pan, Li; Stuber, Matthias; Kraitchman, Dara L et al. (2006) Real-time imaging of regional myocardial function using fast-SENC. Magn Reson Med 55:386-95
Kraitchman, Dara L; Tatsumi, Mitsuaki; Gilson, Wesley D et al. (2005) Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation 112:1451-61
Bulte, Jeff W M; Kraitchman, Dara L (2004) Monitoring cell therapy using iron oxide MR contrast agents. Curr Pharm Biotechnol 5:567-84
Amado, Luciano C; Gerber, Bernhard L; Gupta, Sandeep N et al. (2004) Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model. J Am Coll Cardiol 44:2383-9
Rosen, Boaz D; Gerber, Bernhard L; Edvardsen, Thor et al. (2004) Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging. Am J Physiol Heart Circ Physiol 287:H1740-6
Bulte, Jeff W M; Kraitchman, Dara L (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17:484-99
Kostura, Lisa; Kraitchman, Dara L; Mackay, Alastair M et al. (2004) Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis. NMR Biomed 17:513-7
Kraitchman, Dara L; Heldman, Alan W; Atalar, Ergin et al. (2003) In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation 107:2290-3
Kraitchman, Dara L; Sampath, Smita; Castillo, Ernesto et al. (2003) Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP. Circulation 107:2025-30