Event-related brain potentials (ERPs), and concomitant behavioral indices will be recorded from normal subjects during studies of cognitive development and aging and from two clinical populations, schizophrenics and patients with Alzheimer's disease, who display specific cognitive deficits. It is expected that the ERP measures will provide insights into the hierarchy, sequencing and timing of information processing that are much more difficult to infer from behavioral data alone. The main goal in the study of normal subjects is a description and analysis of the changes in the electrical activity of the normally aging brain, with a view toward a better understanding of age-related changes in semantic processing and memory function. In the study of schizophrenia and Alzheimer's disease, the cognitive ERPs will be elicited during tasks designed specifically to tap the functions for which these disordered subjects show deficits. Comparison of the disordered groups' ERPs with those recorded from normal samples will allow an assessment of which stages of information processing are deficient in these populations and should, in turn, allow more precise functional definitions of the endogenous ERP components. During the tenure of the award, the principal investigator will develop greater expertise in the application of topographical methods to the cognitive ERPs and, via collaboration and consultation, will gain additional knowledge in the area of risk research, in the application of cognitive methodology to development and aging, and in the application of ERP technology to patients with localized brain damage.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
2K02MH000510-06
Application #
3069878
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1984-09-15
Project End
1994-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Berman, S; Friedman, D (1995) The development of selective attention as reflected by event-related brain potentials. J Exp Child Psychol 59:1-31
Hamberger, M J; Friedman, D; Ritter, W et al. (1995) Event-related potential and behavioral correlates of semantic processing in Alzheimer's patients and normal controls. Brain Lang 48:33-68
Friedman, D; Squires-Wheeler, E; Erlenmeyer-Kimling, L (1995) Subjects at risk for psychopathology from the New York High Risk Project: ERPs during adolescence and clinical outcomes in young adulthood. Electroencephalogr Clin Neurophysiol Suppl 44:379-86
Fabiani, M; Friedman, D (1995) Changes in brain activity patterns in aging: the novelty oddball. Psychophysiology 32:579-94
Friedman, D; Squires-Wheeler, E (1994) Event-related potentials (ERPs) as indicators of risk for schizophrenia. Schizophr Bull 20:63-74
Friedman, D; Simpson, G V (1994) ERP amplitude and scalp distribution to target and novel events: effects of temporal order in young, middle-aged and older adults. Brain Res Cogn Brain Res 2:49-63
Friedman, D; Snodgrass, J G; Ritter, W (1994) Implicit retrieval processes in cued recall: implications for aging effects in memory. J Clin Exp Neuropsychol 16:921-38
Towey, J P; Tenke, C E; Bruder, G E et al. (1994) Brain event-related potential correlates of overfocused attention in obsessive-compulsive disorder. Psychophysiology 31:535-43
Squires-Wheeler, E; Friedman, D; Skodol, A E et al. (1993) A longitudinal study relating P3 amplitude to schizophrenia spectrum disorders and to global personality functioning. Biol Psychiatry 33:774-85
Towey, J; Bruder, G; Tenke, C et al. (1993) Event-related potential and clinical correlates of neurodysfunction in obsessive-compulsive disorder. Psychiatry Res 49:167-81

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