On the panic disorder project 21 multiplex pedigrees have been collected and typed for over 200RFLP markers. A candidate gene study of the adrenergic receptor loci was also completed. The next objectives will be to add five pedigrees per year over the next three years, and to type 300- 500 short tandem repeat markers covering the entire human genome. On the schizophrenia project, 15 multiplex pedigrees have been completed and two more will be completed shortly.Three regions of interest have been examined for linkage and no vulnerability loci were detected. These regions include chromosome 5q11-q13, 11q, and the pseudoautosomal region of the sex chromosomes. The next objectives are to add three pedigrees per year for the next three years, to study genomic regions of interest and candidate genes, and to pool the pedigrees with those of other groups in a collaborative genome search.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH000735-07
Application #
2239965
Study Section
Molecular, Cellular, and Developmental Neurobiology Review Committee (MCDN)
Project Start
1988-07-01
Project End
1998-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Iowa
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Logue, Mark W; Bauver, Sarah R; Knowles, James A et al. (2012) Multivariate analysis of anxiety disorders yields further evidence of linkage to chromosomes 4q21 and 7p in panic disorder families. Am J Med Genet B Neuropsychiatr Genet 159B:274-80
Philibert, Robert A; Nelson, Jeffrey J; Bedell, Bruce et al. (2003) Role of elastin polymorphisms in panic disorder. Am J Med Genet B Neuropsychiatr Genet 117B:7-10
Crowe, R R; Goedken, R; Samuelson, S et al. (2001) Genomewide survey of panic disorder. Am J Med Genet 105:105-9
Wang, Z; Valdes, J; Noyes, R et al. (1998) Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder. Am J Med Genet 81:228-34
Garvey, M J; Crowe, R R; Wang, Z (1998) An association of NAG levels and a mutation of the CCK gene in panic disorder patients. Psychiatry Res 80:149-53
Wang, Z W; Black, D; Andreasen, N C et al. (1993) A linkage study of chromosome 11q in schizophrenia. Arch Gen Psychiatry 50:212-6
Schmidt, S M; Zoega, T; Crowe, R R (1993) Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. Acta Psychiatr Scand 88:225-8
Crowe, R R (1993) Candidate genes in psychiatry: an epidemiological perspective. Am J Med Genet 48:74-7
Wang, Z W; Black, D; Andreasen, N et al. (1993) Pseudoautosomal locus for schizophrenia excluded in 12 pedigrees. Arch Gen Psychiatry 50:199-204
Wang, Z; Crowe, R R; Tanna, V L et al. (1992) Alpha 2 adrenergic receptor subtypes in depression: a candidate gene study. J Affect Disord 25:191-6

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