This is a competing renewal of Dr. Michael V. Vitiello's NIMH Independent Scientist Award, K02-MH01158, Age-Related Sleep Disturbance Possible Interventions. As much as 40% of the older population complains of significant, chronic sleep disturbance. Sleep complaints often lead to chronic sedative hypnotic use and the elderly receive a disproportionate number of such prescriptions. Sedative-hypnotics offer short-term relief but their long-term efficacy is unclear and chronic use has been associated with increased morbidity and mortality. A recent NIH Consensus Conference concluded that chronic hypnotic use is inappropriate and that non-sedative interventions for sleep disruption are sorely needed. Dr. Vitiello proposes three specific aims that will examine possible non-sedative hypnotic approaches to improving the sleep quality of the elderly:
Specific Aim 1 : Examine the usefulness of fitness training interventions to improve the sleep quality of older men and women.
Specific Aim 2 : Examine the usefulness of neuroendocrine interventions (e.g., growth hormone releasing hormone, estrogen, and testosterone supplementation) to improve the sleep quality of older men and women.
Specific Aim 3 : Examine the usefulness of cognitive behavioral techniques to improve the sleep quality of older men and women in a number of different settings. While pursuing these aims, Dr. Vitiello will develop additional expertise in the interactions of sex steroids and sleep quality, ambulatory monitoring of sleep and respiration, actigraphic recording of rest/activity rhythms and cognitive behavioral interventions for sleep disturbance in the elderly. Each of these proposed lines of research has considerable significance for our understanding of the causes of,and potential treatments for, sleep disturbance in the aged. Effective non- sedative interventions may significantly improve not only sleep quality but also overall the quality of life in the elderly. Further, such interventions may have significant impact in decreasing morbidity and mortality directly related to such sleep disturbance or its inappropriate treatment with chronic hypnotic medications.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research (K02)
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Study Section
Mental Disorders of Aging Review Committee (MDA)
Program Officer
Olin, Jason T
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University of Washington
Schools of Medicine
United States
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McCurry, Susan M; Vitiello, Michael V; Gibbons, Laura E et al. (2006) Factors associated with caregiver reports of sleep disturbances in persons with dementia. Am J Geriatr Psychiatry 14:112-20
Vitiello, Michael V; Moe, Karen E; Merriam, George R et al. (2006) Growth hormone releasing hormone improves the cognition of healthy older adults. Neurobiol Aging 27:318-23
McCurry, Susan M; Gibbons, Laura E; Logsdon, Rebecca G et al. (2005) Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial. J Am Geriatr Soc 53:793-802
Tworoger, Shelley S; Davis, Scott; Vitiello, Michael V et al. (2005) Factors associated with objective (actigraphic) and subjective sleep quality in young adult women. J Psychosom Res 59:11-9
Anderson, Gail D; Elmer, Gary W; Kantor, Eric D et al. (2005) Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. Phytother Res 19:801-3
McCurry, Susan M; Logsdon, Rebecca G; Vitiello, Michael V et al. (2004) Treatment of sleep and nighttime disturbances in Alzheimer's disease: a behavior management approach. Sleep Med 5:373-7
Vitiello, Michael V; Larsen, Lawrence H; Moe, Karen E (2004) Age-related sleep change: Gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women. J Psychosom Res 56:503-10
Banerjee, Dev; Vitiello, Michael V; Grunstein, Ronald R (2004) Pharmacotherapy for excessive daytime sleepiness. Sleep Med Rev 8:339-54
Merriam, George R; Schwartz, Robert S; Vitiello, Michael V (2003) Growth hormone-releasing hormone and growth hormone secretagogues in normal aging. Endocrine 22:41-8
McCurry, Susan M; Gibbons, Laura E; Logsdon, Rebecca G et al. (2003) Training caregivers to change the sleep hygiene practices of patients with dementia: the NITE-AD project. J Am Geriatr Soc 51:1455-60

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