This is an application for an RSDA KO2 award to the National Institute of Mental Health. It addresses the emotional and performance sequelae of l) acute total sleep loss, 2) chronic partial sleep loss, and 3) circadian desynchrony, in healthy adult men and women.
The aim of the research is to more fully understand what happens to the mood, activation and performance of people under conditions becoming ever more prevalent in today's society. The emphasis will be on explanations that go beyond simple measures of sleepiness and failures to respond, exploring the changes in affect and information-processing ability in greater detail. The approach taken will recognize that performance decrements may occur both directly from the sleep loss and/or circadian desynchrony per se, and indirectly through the changes these stressors induce in the mood or emotional status of the individual. Apart from the obvious applied ramifications of this work regarding public wellbeing, safety and competitiveness, we consider these effects to be potential precursors to first occurrences of syndromal and sub-syndromal depression in vulnerable individuals, and to recurrence of depression in others.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research (K02)
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Clinical Neuroscience Review Committee (CNR)
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University of Pittsburgh
Schools of Medicine
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Carrier, J; Monk, T H (2000) Circadian rhythms of performance: new trends. Chronobiol Int 17:719-32
Monk, T H (2000) What can the chronobiologist do to help the shift worker? J Biol Rhythms 15:86-94
Monk, T H; Buysse, D J; Rose, L R (1999) Wrist actigraphic measures of sleep in space. Sleep 22:948-54
Monk, T H; Buysse, D J; Billy, B D et al. (1998) Sleep and circadian rhythms in four orbiting astronauts. J Biol Rhythms 13:188-201
Monk, T H; Buysse, D J; Billy, B D et al. (1997) The effects on human sleep and circadian rhythms of 17 days of continuous bedrest in the absence of daylight. Sleep 20:858-64
Tu, X M; Kowalski, J; Randall, J et al. (1997) Generalized covariance-adjusted discriminants: perspective and application. Biometrics 53:900-9
Monk, T H; Buysse, D J; Reynolds 3rd, C F et al. (1997) Circadian rhythms in human performance and mood under constant conditions. J Sleep Res 6:9-18
Monk, T H; Carrier, J (1997) Speed of mental processing in the middle of the night. Sleep 20:399-401
Monk, T H; Reynolds 3rd, C F; Kupfer, D J et al. (1997) Differences over the life span in daily life-style regularity. Chronobiol Int 14:295-306
Carrier, J; Monk, T H (1997) Estimating the endogenous circadian temperature rhythm without keeping people awake. J Biol Rhythms 12:266-77

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