For several years, several child and adolescent onset disorders, including autistic disorder, attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and major depressive disorder, have been shown to have varying degrees of genetic influence. However, there has been no consistent evidence that they are explained by single genes, or by genetic factors alone. Recent developments in molecular and statistical aspects of genetics have made the study of such complex disorders feasible. The first research component of the independent scientist award is to collect 350 carefully diagnosed subjects with autistic disorder. The Autism Diagnostic Interview and Autism Diagnostic Observation Schedule will be used in addition to diagnosis of autistic disorder by both the examining child and adolescent psychologist and child and adolescent psychiatrist. Cross-site reliability will be maintained. DNA will be collected from both the proband and his/her parents. The transmission/disequilibrium test (TdT) will be used to determine whether alleles at candidate loci are preferentially transmitted. In addition, this data base will be available for replication of any susceptibility loci identified in other samples. In a previous study, linkage disequilibrium between attention-deficit/hyperactivity disorder and a genetic marker at the dopamine transporter locus has been identified. A second research component of the independent scientist development plan will be a study designed to replicate the initial study with addition of a structured diagnostic interview. In collaboration with other colleagues, genetic analyses of childhood onset major depressive disorder (TdT of candidate genes) will be conducted. An emphasis will be placed on collecting DNA from subjects with reliably and valid diagnoses to provide a data base for molecular genetic studies severe disorders of children and adolescents. Consultants in diagnostic methodology and genetic analysis will meet regularly with the candidate to provide guidance for ongoing research career development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001389-02
Application #
2655346
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Program Officer
Moldin, Steven Owen
Project Start
1997-02-01
Project End
2002-01-31
Budget Start
1998-02-01
Budget End
1999-01-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Dickel, Diane E; Veenstra-VanderWeele, Jeremy; Cox, Nancy J et al. (2006) Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry 63:778-85
Lamb, J A; Barnby, G; Bonora, E et al. (2005) Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects. J Med Genet 42:132-7

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