The PI is a Neurophysiologist and Pediatric Neurosurgeon who will be the Associate Director of Center V (Behavioral and Neurobiology Research), with special responsibility for Neurobiology programs, at the Children""""""""s Research Institute. This RCA will permit the PI to devote nearly full time to research. Short term goals are to test the hypothesis that neuronal ensembles have nonlinear deterministic properties. If so, they will 1) have activity that can be characterized and controlled through unstable periodic orbits, 2) hen noise driven will exhibit stochastic resonance, and 3) because of coupling will exhibit generalized (nonlinear) synchrony and emergence. Long-term goals are to achieve a better understanding of neuronal network and brain behavior, and to develop novel methods of treating dynamical diseases. The research project will involve theoretical work on the detection of unstable orbits in In Vitro brain slices and human epileptic foci. Such orbit information forms a novel method of characterizing the deterministic properties of complex systems despite nonstationarity, and can be used to control those systems. Nonlinear systems also optimize their response to weak signals in the presence of noise - stochastic resonance. We will define the statistical mechanics of stochastic resonance through simultaneous measurements of single neuron and neuronal ensemble activity. Since neuronal ensembles may demonstrate nonlinear generalized synchrony, we will quantify spatio-temporal generalized synchrony through dual simultaneous single cell recordings as a function of separation in a neuronal network. Both unstable orbit detection and generalized synchrony will be used to define the emergence of nonlinear behaviors in neuronal ensembles. The results of this research will fundamentally alter the way that neuronal dynamics can be characterized and controlled, will provide a means to deal with neuronal nonstationarity, will further explain the role of noise in the nervous system, and may provide a novel approach for the control of pathological neuronal ensembles in dynamical diseases such as epilepsy, spasticity, and tremor.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001493-04
Application #
6185560
Study Section
Cognitive Functional Neuroscience Review Committee (CFN)
Program Officer
Glanzman, Dennis L
Project Start
1997-09-30
Project End
2002-05-31
Budget Start
2000-06-05
Budget End
2001-05-31
Support Year
4
Fiscal Year
2000
Total Cost
$99,063
Indirect Cost
Name
George Mason University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
077817450
City
Fairfax
State
VA
Country
United States
Zip Code
22030
La Corte, Giorgio; Wei, Yina; Chernyy, Nick et al. (2014) Frequency dependence of behavioral modulation by hippocampal electrical stimulation. J Neurophysiol 111:470-80
Ingram, Justin; Zhang, Chunfeng; Cressman, John R et al. (2014) Oxygen and seizure dynamics: I. Experiments. J Neurophysiol 112:205-12
Ziburkus, Jokubas; Cressman, John R; Schiff, Steven J (2013) Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. J Neurophysiol 109:1296-306
Berzhanskaya, Julia; Chernyy, Nick; Gluckman, Bruce J et al. (2013) Modulation of hippocampal rhythms by subthreshold electric fields and network topology. J Comput Neurosci 34:369-89
Ingram, Justin M; Zhang, Chunfeng; Xu, Jian et al. (2013) FRET excited ratiometric oxygen sensing in living tissue. J Neurosci Methods 214:45-51
Kamrunnahar, M; Dias, N S; Schiff, S J (2011) Toward a model-based predictive controller design in brain-computer interfaces. Ann Biomed Eng 39:1482-92
Riester, Markus; Stephan-Otto Attolini, Camille; Downey, Robert J et al. (2010) A differentiation-based phylogeny of cancer subtypes. PLoS Comput Biol 6:e1000777
Dias, N S; Kamrunnahar, M; Mendes, P M et al. (2010) Feature selection on movement imagery discrimination and attention detection. Med Biol Eng Comput 48:331-41
Ullah, Ghanim; Schiff, Steven J (2010) Assimilating seizure dynamics. PLoS Comput Biol 6:e1000776
Chernyy, Nick; Schiff, Steven J; Gluckman, Bruce J (2009) Time dependence of stimulation/recording-artifact transfer function estimates for neural interface systems. Conf Proc IEEE Eng Med Biol Soc 2009:1380-3

Showing the most recent 10 out of 43 publications