This is a request for an NIH Independent Scientist Award (K02) to enhance the Pl's ability to contribute to the understanding of the processes underlying the development of depressive disorders in children and adolescents and to develop and test interventions aimed at preventing depression in youth. The Pl's research program has evolved from studying psychosocial risk factors that predict depression in children and adolescents, to examining the role of these risk factors as mediators of the link between parent and child psychopathology, to testing a prevention program that targets several of the risk factors identified in the earlier studies. This proposal describes three research programs involving five different but related studies. The first program includes two separate longitudinal studies that examine the contribution of varbus psychosocial factors (e.g., family dysfunction, social feedback, stress) to the development of negative cognitions and depressive disorders in children and adolescents. The second program is comprised of two different investigations of whether decreases in parents' depression as a result of treatment (cognitive-behavioral and/or pharmacotherapy) are associated with changes in their children's psychopathology and functioning, and whether these changes are mediated by improvements in parent-child relationships, negative cognitions, and/or decreases in stressful life events. The last project uses knowledge about risk factors learned from the first two research programs to test a cognitive-behavioral intervention for preventing depression in adolescents at risk for mood disorders due to their having a parent in treatment for depression, and themselves having either a past depressive ecandidatesode or current subsyndromal depressive symptoms. The goal of the career development plan is to expand the candidate's skills in two areas: quantitative methods and prevention science. Because most of the candidate's research is longitudinal, learning state-of-the-art statistical methods (e.g. latent growth curve, linear and non-linear mixed effects models, survival analysis, structural equations modeling) will broaden the kinds of research questions that can be addressed with both existing and new data. In addition, she will update and expand her knowledge of preventive interventions, particularly cognitive-behavioral approaches, with the aim of further developing and testing the efficacy of programs for preventing depression in high-risk adolescents. This K award will allow the candidate to bridge emcandidaterical research with practice by using basic knowledge about etiology to address the practical problem of preventing the onset and recurrence of the serious public health condition of depression, particularly among those at greatest risk for the disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH066249-04
Application #
7035315
Study Section
Risk, Prevention and Health Behavior Integrated Review Group (RPHB)
Program Officer
Goldstein, Amy B
Project Start
2003-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
4
Fiscal Year
2006
Total Cost
$118,487
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Psychology
Type
Schools of Education
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Deboeck, Pascal R; Nicholson, Jody; Kouros, Chrystyna et al. (2016) Integrating developmental theory and methodology: Using derivatives to articulate change theories, models, and inferences. Appl Dev Sci 19:217-231
Kouros, Chrystyna D; Morris, Matthew C; Garber, Judy (2016) Within-Person Changes in Individual Symptoms of Depression Predict Subsequent Depressive Episodes in Adolescents: a Prospective Study. J Abnorm Child Psychol 44:483-94
Evans, Lindsay D; Kouros, Chrystyna; Frankel, Sarah A et al. (2015) Longitudinal relations between stress and depressive symptoms in youth: coping as a mediator. J Abnorm Child Psychol 43:355-68
Kouros, Chrystyna D; Garber, Judy (2014) Trajectories of individual depressive symptoms in adolescents: gender and family relationships as predictors. Dev Psychol 50:2633-43
Kouros, Chrystyna D; Quasem, Susanna; Garber, Judy (2013) Dynamic temporal relations between anxious and depressive symptoms across adolescence. Dev Psychopathol 25:683-97
Pössel, Patrick; Martin, Nina C; Garber, Judy et al. (2013) A randomized controlled trial of a cognitive-behavioral program for the prevention of depression in adolescents compared with nonspecific and no-intervention control conditions. J Couns Psychol 60:432-8
James, Jenee; Ellis, Bruce J; Schlomer, Gabriel L et al. (2012) Sex-specific pathways to early puberty, sexual debut, and sexual risk taking: tests of an integrated evolutionary-developmental model. Dev Psychol 48:687-702
Carter, Jocelyn Smith; Garber, Judy (2011) Predictors of the first onset of a major depressive episode and changes in depressive symptoms across adolescence: stress and negative cognitions. J Abnorm Psychol 120:779-96
Wickramaratne, Priya; Gameroff, Marc J; Pilowsky, Daniel J et al. (2011) Children of depressed mothers 1 year after remission of maternal depression: findings from the STAR*D-Child study. Am J Psychiatry 168:593-602
Cole, David A; Cai, Li; Martin, Nina C et al. (2011) Structure and measurement of depression in youths: applying item response theory to clinical data. Psychol Assess 23:819-33

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