Abstract

Schizophrenia is a pan-cerebral illness, affecting almost every modality, function, and brain region studied. My career incorporates applications of electrophysiological techniques to understand deficits in elemental mechanisms at the root of some of the dysfunctions observed. My career goals include: Enhancing skills in time-frequency analysis of electroencephalogram (EEG) and electro-corticogram (ECoG) data collected as part of the linked R01;Applying these skills and new ones for the analysis of magnetoencephalogram (MEG) data collected as part of the current K02 and the renewal of the K02: Applying these skills to assess effects of cognitive remediation in chronic schizophrenia patients;Applying these skills to assess deficits in patients during the prodromal phase of schizophrenia;Applying these skills to data I propose to collect for my R01 linked to this K02 award and obtaining a T32 to enable funded mentoring activities. My research goals include: Exploring neural synchrony deficits in patients with prodromal symptoms of schizophrenia and exploring effects of cognitive remediation on neural synchrony in patients with schizophrenia. I co-direct the Laboratory of Clinical and Cognitive Neuroscience with Dr. Daniel Mathalon at Yale. We are both considering moving our laboratory from Yale to UCSF, but would be leaving a skeleton crew at the EEG labs at Yale. The goals of this career award, and the linked R01, can be met at either institution. Testing patients before and after cognitive remediation (K02) would be done at Yale with Drs. Bell and Wexler whether or not I move, and at UCSF with Drs. Vinogradov and Merzenich, if I do move. The addition of prodromal patients (K02) would be done with Dr. Mathalon who will be working in collaboration with Dr. Vinogradov at UCSF and Dr. Woods at Yale. The intra-cranial studies (R01) would be done at Yale with Drs. Cavus and Spencer whether or not I move, and at UCSF with Dr. Knight if I do move. The MEG (K02) project would be done only at UCSF with Dr. Houde. If I do not move, I will complete it during frequent visits to my family in the Bay Area. The goals of the R01, not directly related to the K02, can also be met;relationships for patient and family recruitment are in place at both sites.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH067967-09
Application #
7678966
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Meinecke, Douglas L
Project Start
2003-09-01
Project End
2013-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
9
Fiscal Year
2009
Total Cost
$153,846
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Psychiatry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Biagianti, Bruno; Roach, Brian J; Fisher, Melissa et al. (2017) Trait aspects of auditory mismatch negativity predict response to auditory training in individuals with early illness schizophrenia. Neuropsychiatr Electrophysiol 3:
Perez, Veronica B; Woods, Scott W; Roach, Brian J et al. (2014) Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity. Biol Psychiatry 75:459-69
Butler, Pamela D; Chen, Yue; Ford, Judith M et al. (2012) Perceptual measurement in schizophrenia: promising electrophysiology and neuroimaging paradigms from CNTRICS. Schizophr Bull 38:81-91
Whitford, Thomas J; Ford, Judith M; Mathalon, Daniel H et al. (2012) Schizophrenia, myelination, and delayed corollary discharges: a hypothesis. Schizophr Bull 38:486-94
Perez, Veronica B; Ford, Judith M; Roach, Brian J et al. (2012) Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis. Schizophr Bull 38:1216-24
Ford, Judith M; Perez, Veronica B; Mathalon, Daniel H (2012) Neurophysiology of a possible fundamental deficit in schizophrenia. World Psychiatry 11:58-60
Ford, Judith M; Mathalon, Daniel H (2012) Anticipating the future: automatic prediction failures in schizophrenia. Int J Psychophysiol 83:232-9
Gunduz-Bruce, Handan; Reinhart, Robert M G; Roach, Brian J et al. (2012) Glutamatergic modulation of auditory information processing in the human brain. Biol Psychiatry 71:969-77
Perez, Veronica B; Ford, Judith M; Roach, Brian J et al. (2012) Error monitoring dysfunction across the illness course of schizophrenia. J Abnorm Psychol 121:372-87
Whitford, T J; Mathalon, D H; Shenton, M E et al. (2011) Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia. Psychol Med 41:959-69

Showing the most recent 10 out of 23 publications