This is an Independent Scientist Award for Warren G. Tourtellotte, M.D., Ph.D. who is currently an Assistant Professor of Pathology, Neurology and Neuroscience at Northwestern University, Feinberg School of Medicine. Dr. Tourtellotte devotes greater than 75% professional effort to research focused on transcriptional regulation of genes involved in central and peripheral nervous system development. This Research Career Award will assure Dr. Tourtellotte stable salary support to allow him to commit 75% professional effort to research. The institution is supportive of a 75% research effort as evidenced by minimized clinical service commitments and recent expansion of the research space available to Dr. Tourtellotte. The career development plan will extend the focus of Egr transcription factor function in the laboratory to include studies of cellular physiology, signal transduction and genome wide regulatory network analysis. Dr. Tourtellotte will use the career development resources to strengthen collaborative networks both within the institution and externally to strengthen the research program by improving the methodology, scientific staff and expertise available to the laboratory. The Research Plan will characterize the role of Egr transcription factors in sympathetic nervous system development, neurotrophin mediated gene regulation and signal transduction. The planned career development activities will take full advantage of the rich collaborative and career development resources available at Northwestern University.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Scientist Development Award - Research (K02)
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NST-2 Subcommittee (NST)
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Mamounas, Laura
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Northwestern University at Chicago
Schools of Medicine
United States
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Tourtellotte, Warren G (2016) Axon Transport and Neuropathy: Relevant Perspectives on the Etiopathogenesis of Familial Dysautonomia. Am J Pathol 186:489-99
Oliveira Fernandes, Michelle; Tourtellotte, Warren G (2015) Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis. J Neurosci 35:5566-78
Jackson, Marisa; Tourtellotte, Warren (2014) Neuron Culture from Mouse Superior Cervical Ganglion. Bio Protoc 4:
Jackson, Marisa Z; Gruner, Katherine A; Qin, Charles et al. (2014) A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation. Development 141:2452-61
Quach, David H; Oliveira-Fernandes, Michelle; Gruner, Katherine A et al. (2013) A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci 33:4570-83
Bhattacharyya, Swati; Wei, Jun; Tourtellotte, Warren G et al. (2012) Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogenesis Tissue Repair 5:S18
Li, Lin; Eldredge, Laurie C; Quach, David H et al. (2011) Egr3 dependent sympathetic target tissue innervation in the absence of neuron death. PLoS One 6:e25696
Eldredge, Laurie C; Gao, Xiaoguang M; Quach, David H et al. (2008) Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice. Development 135:2949-57
Gao, Xiaoguang; Daugherty, Rebecca L; Tourtellotte, Warren G (2007) Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators. Mol Cell Neurosci 36:501-14
Carter, John H; Lefebvre, Juliet M; Wiest, David L et al. (2007) Redundant role for early growth response transcriptional regulators in thymocyte differentiation and survival. J Immunol 178:6796-805

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