This proposal examines spatial bias and distraction in near and far extrapersonal space. The Candidate previously observed far asymmetric attention in a patient with driving problems post-stroke. Far bias has both pragmatic and theoretical implications: it might induce impaired drivers to veer, causing accidents. Asymmetric visual-motor behavior in brain-injured subjects may be due to biased perceptual-attentional (PA) systems, biased motor-intentional (MI) systems, combined bias, or other factors. In five experiments, the Candidate will assess the proportion of error accounted for by PA and MI bias as subjects perform a video procedure in near and far space. In Experiments 1 & 2, she will manipulate performance-monitoring conditions to estimate PA/MI components of attentional bias and distractibility in near versus far space in post-stroke spatial neglect. Since months post-stroke, patients who have recovered on conventional visual-spatial tasks may still be still functionally disabled, in Experiment 3 the Candidate will examine whether separating PA and MI bias allows detection of persistent pathological errors. The Candidate will assess patients acutely post-stroke, and then repeatedly over a subsequent six months, examining evolution of near/far PA and MI bias. In Experiment 4, the Candidate will examine how monocular patching, amantadine, and combined treatment influence near/far spatial bias and distractibility. In Experiment 5, post-stroke subjects with presumed non-pathologic bias (compensated hemianopia) are compared with subjects with pathologic bias (contralateral/ipsilateral neglect) on the previous experiments. Considerable clinical and scientific training prepared the Candidate to begin this independent phase of her career. The Independent Clinical Investigator Award (K02) will provide essential time and resources as she continues her academic development. The present studies may clarify the neuropsychological mechanisms of orienting and visual-motor bias in near and far space after brain injury, contributing to the literature on brain attentional systems. However, this work may also advance understanding of safe and adaptive movement in complex environments by neurologically-impaired persons, improving their driving and functional independence. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02NS047099-03
Application #
6889243
Study Section
NST-2 Subcommittee (NST)
Program Officer
Babcock, Debra J
Project Start
2004-05-01
Project End
2009-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
3
Fiscal Year
2005
Total Cost
$168,670
Indirect Cost
Name
Kessler Foundation, Inc.
Department
Type
DUNS #
029128969
City
West Orange
State
NJ
Country
United States
Zip Code
07052
Caulfield, Meghan D; Chen, Peii; Barry, Michele M et al. (2017) Which perseverative behaviors are symptoms of spatial neglect? Brain Cogn 113:93-101
Houston, Kevin E; Paschalis, Eleftherios I; Angueira, Danielle C et al. (2017) Restoration of Vision After Brain Injury Using Magnet Glasses. Am J Phys Med Rehabil 96:e70-e74
Wagner, Daymond; Eslinger, Paul J; Barrett, A M (2016) Decreased leftward 'aiming' motor-intentional spatial cuing in traumatic brain injury. Neuropsychology 30:731-41
Sacchetti, Daniela L; Goedert, Kelly M; Foundas, Anne L et al. (2015) Ipsilesional neglect: behavioral and anatomical correlates. Neuropsychology 29:183-90
Goedert, Kelly M; Chen, Peii; Boston, Raymond C et al. (2014) Presence of Motor-Intentional Aiming Deficit Predicts Functional Improvement of Spatial Neglect With Prism Adaptation. Neurorehabil Neural Repair 28:483-93
Galletta, Elizabeth E; Campanelli, Luca; Maul, Kristen K et al. (2014) Assessment of neglect dyslexia with functional reading materials. Top Stroke Rehabil 21:75-86
McKenna, Cristin; Thakur, Uma; Marcus, Bradley et al. (2013) Assessing limb apraxia in traumatic brain injury and spinal cord injury. Front Biosci (Schol Ed) 5:732-42
Chen, Peii; Goedert, Kelly M (2012) Clock drawing in spatial neglect: a comprehensive analysis of clock perimeter, placement, and accuracy. J Neuropsychol 6:270-89
Whyte, John; Barrett, A M (2012) Advancing the evidence base of rehabilitation treatments: a developmental approach. Arch Phys Med Rehabil 93:S101-10
Shah, Priyanka P; Gonzalez, Keith O; Barrett, A M (2012) Line copying: distinct ""where"" and ""aiming"" spatial bias in healthy adults. Cogn Behav Neurol 25:77-84

Showing the most recent 10 out of 41 publications