Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Modified Research Career Development Award (K04)
Project #
5K04AG000676-02
Application #
2048526
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Lesnefsky, Edward J; He, DingChao; Moghaddas, Shadi et al. (2006) Reversal of mitochondrial defects before ischemia protects the aged heart. FASEB J 20:1543-5
Lesnefsky, Edward J; Chen, Qun; Moghaddas, Shadi et al. (2004) Blockade of electron transport during ischemia protects cardiac mitochondria. J Biol Chem 279:47961-7
Lesnefsky, Edward J; Chen, Qun; Slabe, Thomas J et al. (2004) Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit heart: role of cardiolipin. Am J Physiol Heart Circ Physiol 287:H258-67
Chen, Qun; Vazquez, Edwin J; Moghaddas, Shadi et al. (2003) Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 278:36027-31
Hoppel, Charles L; Moghaddas, Shadi; Lesnefsky, Edward J (2002) Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart. Biogerontology 3:41-4
Lesnefsky, E J; Slabe, T J; Stoll, M S et al. (2001) Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria. Am J Physiol Heart Circ Physiol 280:H2770-8
Lesnefsky, E J; Moghaddas, S; Tandler, B et al. (2001) Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure. J Mol Cell Cardiol 33:1065-89
Lesnefsky, E J; Gudz, T I; Moghaddas, S et al. (2001) Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site. J Mol Cell Cardiol 33:37-47
Lesnefsky, E J; Gudz, T I; Migita, C T et al. (2001) Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III. Arch Biochem Biophys 385:117-28
Lesnefsky, E J; Stoll, M S; Minkler, P E et al. (2000) Separation and quantitation of phospholipids and lysophospholipids by high-performance liquid chromatography. Anal Biochem 285:246-54

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