The premise of this work is that there are characteristic constant region gene products on T cell receptors and that these isotypes are important in cellular collaboration mechanisms. It has been shown that VH gene products are shared between T and B cells and that anti-VH antibodies are capable of triggering T cells to enter the regulatory network controlling the synthesis of antibody. The hypothesis outlined here is that VH genes are translocated onto characteristic Igh-Tc genes located between Ig-1 and prealbumin on chromosome 12 and that the function of the recombined gene product is the key to the interaction patterns of T lymphocytes which modulate the cellular wing of the immune response. A serological approach will be used for immuno-precipitation studies of the molecular properties of T cell receptors and for induction of the biological activities attributed to subsets of T cells. The existence of discrete isotypes on T cells and their possible role in triggering and regulation of cell function will be explored and compared with the known isotypes characteristic of the B cell repetoire.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Modified Research Career Development Award (K04)
Project #
5K04AI000546-05
Application #
3070665
Study Section
Immunobiology Study Section (IMB)
Project Start
1983-08-01
Project End
1988-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111