Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Modified Research Career Development Award (K04)
Project #
5K04AI000721-05
Application #
3070792
Study Section
Virology Study Section (VR)
Project Start
1986-09-01
Project End
1991-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Blair, W S; Semler, B L (1991) Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase. J Virol 65:6111-23
Dildine, S L; Stark, K R; Haller, A A et al. (1991) Poliovirus translation initiation: differential effects of directed and selected mutations in the 5' noncoding region of viral RNAs. Virology 182:742-52
Giachetti, C; Semler, B L (1991) Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis. J Virol 65:2647-54
Lawson, M A; Dasmahapatra, B; Semler, B L (1990) Species-specific substrate interaction of picornavirus 3C proteinase suballelic exchange mutants. J Biol Chem 265:15920-31
Fu, J L; Stein, S; Rosenstein, L et al. (1990) Neurovirulence determinants of genetically engineered Theiler viruses. Proc Natl Acad Sci U S A 87:4125-9
Dewalt, P G; Blair, W S; Semler, B L (1990) A genetic locus in mutant poliovirus genomes involved in overproduction of RNA polymerase and 3C proteinase. Virology 174:504-14
Blair, W S; Hwang, S S; Ypma-Wong, M F et al. (1990) A mutant poliovirus containing a novel proteolytic cleavage site in VP3 is altered in viral maturation. J Virol 64:1784-93
Lawson, M A; Semler, B L (1990) Picornavirus protein processing--enzymes, substrates, and genetic regulation. Curr Top Microbiol Immunol 161:49-87
Roos, R P; Stein, S; Ohara, Y et al. (1989) Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J Virol 63:5492-6
Dewalt, P G; Lawson, M A; Colonno, R J et al. (1989) Chimeric picornavirus polyproteins demonstrate a common 3C proteinase substrate specificity. J Virol 63:3444-52

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