Abstract

From its initial focus on chlamydial molecular pathogenesis and intracellular development, this research program has expanded to include a second objective: the development of a vaccine against blinding trachoma, a-widespread sequela of chlamydial ocular disease in developing countries. The initiation of this project was greatly facilitated by the considerable overlap in reagents and technologies with his prior interest and the development of key collaborations with established immunologists at the University of Rochester and at the University of Arkansas for Medical Sciences. The research objectives are: the functional and structural characterization of a chlamydial adhesin, the study of the role of a chlamydial chaperonin in the synthesis/assembly of the chlamydial cell wall, and the identification of chlamydial protective antigens and their evaluation as vaccine components.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Modified Research Career Development Award (K04)
Project #
5K04AI001057-04
Application #
2057075
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1992-09-30
Project End
1996-06-30
Budget Start
1995-09-01
Budget End
1996-06-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Shin, Dong-Mi; Shaffer, Daniel J; Wang, Hongsheng et al. (2008) NOTCH is part of the transcriptional network regulating cell growth and survival in mouse plasmacytomas. Cancer Res 68:9202-11
Hsia, R C; Ting, L M; Bavoil, P M (2000) Microvirus of chlamydia psittaci strain guinea pig inclusion conjunctivitis: isolation and molecular characterization. Microbiology 146 ( Pt 7):1651-60
Bavoil, P M; Hsia, R; Ojcius, D M (2000) Closing in on Chlamydia and its intracellular bag of tricks. Microbiology 146 ( Pt 11):2723-31
Hsia, R; Ohayon, H; Gounon, P et al. (2000) Phage infection of the obligate intracellular bacterium, Chlamydia psittaci strain guinea pig inclusion conjunctivitis. Microbes Infect 2:761-72
Gutierrez-Martin, C B; Ojcius, D M; Hsia, R et al. (1997) Heparin-mediated inhibition of Chlamydia psittaci adherence to HeLa cells. Microb Pathog 22:47-57
Hsia, R C; Pannekoek, Y; Ingerowski, E et al. (1997) Type III secretion genes identify a putative virulence locus of Chlamydia. Mol Microbiol 25:351-9
Hsia, R C; Bavoil, P M (1996) Homologs of Escherichia coli recJ, gltX and of a putative 'early' gene of avian Chlamydia psittaci are located upstream of the 'late' omp2 locus of Chlamydia psittaci strain guinea pig inclusion conjunctivitis. Gene 176:163-9
Hsia, R C; Bavoil, P M (1996) Sequence analysis of the omp2 region of Chlamydia psittaci strain GPIC: structural and functional implications. Gene 176:155-62
Ting, L M; Hsia, R C; Haidaris, C G et al. (1995) Interaction of outer envelope proteins of Chlamydia psittaci GPIC with the HeLa cell surface. Infect Immun 63:3600-8
Rank, R G; Dascher, C; Bowlin, A K et al. (1995) Systemic immunization with Hsp60 alters the development of chlamydial ocular disease. Invest Ophthalmol Vis Sci 36:1344-51

Showing the most recent 10 out of 13 publications