Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Modified Research Career Development Award (K04)
Project #
5K04AI001229-03
Application #
2057400
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1994-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kremer, I B; Gould, M P; Cooper, K D et al. (2001) Pretreatment with recombinant Flt3 ligand partially protects against progressive cutaneous leishmaniasis in susceptible BALB/c mice. Infect Immun 69:673-80
Martin, D L; King, C L; Pearlman, E et al. (2000) IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol 164:779-85
Heinzel, F P; Maier Jr, R A (1999) Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody. Infect Immun 67:6454-60
Sang, D K; Ouma, J H; John, C C et al. (1999) Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis. J Infect Dis 179:743-6
Heinzel, F P; Rerko, R M (1999) Cure of progressive murine leishmaniasis: interleukin 4 dominance is abolished by transient CD4(+) T cell depletion and T helper cell type 1-selective cytokine therapy. J Exp Med 189:1895-906
Balkhy, H H; Heinzel, F P (1999) Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: deficiencies in both IL-12 heterodimer production and IL-12 responsiveness. J Immunol 162:3633-8
Heinzel, F P; Rerko, R M; Hujer, A M et al. (1998) Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major. Infect Immun 66:4537-40
Heinzel, F P; Rerko, R M; Hujer, A M (1998) Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity. Cell Immunol 184:129-42
Heinzel, F P; Hujer, A M; Ahmed, F N et al. (1997) In vivo production and function of IL-12 p40 homodimers. J Immunol 158:4381-8
Heinzel, F P; Rerko, R M; Ahmed, F et al. (1996) IFN-gamma-independent production of IL-12 during murine endotoxemia. J Immunol 157:4521-8

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