Abstract

The role of p53 in the regulation of MDR1 expression is crucial to the understanding of the mechanisms of development of the multidrug resistance phenotype in cancers. Results from these studies could have significant implications for the activation of the MDR1 gene during tumor progression associated with genetic alterations in p53, and could potentially provide novel alternatives to the development and design of specific treatment strategies for human malignancies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
1K04CA067722-01
Application #
2111482
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-05-01
Project End
2000-04-30
Budget Start
1995-05-01
Budget End
1996-04-30
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Chin, Khew-Voon; Seifer, David B; Feng, Bo et al. (2002) DNA microarray analysis of the expression profiles of luteinized granulosa cells as a function of ovarian reserve. Fertil Steril 77:1214-8
Kudoh, K; Ramanna, M; Ravatn, R et al. (2000) Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Cancer Res 60:4161-6
Cvijic, M E; Kita, T; Shih, W et al. (2000) Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer. Clin Cancer Res 6:2309-17
Ishii, K; Yang, W L; Cvijic, M E et al. (2000) Telomere shortening by cisplatin in yeast nucleotide excision repair mutant. Exp Cell Res 255:95-101
Lee, C H; Sidik, K; Chin, K V (1999) Nonradioactive detection of DNA repair synthesis. Mol Biotechnol 11:263-6
Yang, W L; Zeng, Y X; El-Deiry, W S et al. (1999) Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha. Mol Cell Biol Res Commun 1:125-31
Cvijic, M E; Yang, W L; Chin, K V (1998) Cisplatin sensitivity in cAMP-dependent protein kinase mutants of Saccharomyces cerevisiae. Anticancer Res 18:3187-92
Yang, W L; Iacono, L; Tang, W M et al. (1998) Novel function of the regulatory subunit of protein kinase A: regulation of cytochrome c oxidase activity and cytochrome c release. Biochemistry 37:14175-80
Yang, W L; Cvijic, M E; Ishii, K et al. (1998) The requirement of yeast Ssl2 (Rad25) for the repair of cisplatin-damaged DNA. Biochem Biophys Res Commun 250:593-7
Cvijic, M E; Chin, K V (1998) Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells. Biochem Biophys Res Commun 249:723-7

Showing the most recent 10 out of 13 publications