An elaborate collection of lymphocytes exists which protect mucosal regions against infectious pathogens. These lymphocytes have been found to be linked, by preferential recirculatory pathways, in what has been termed a """"""""common mucosal immune system"""""""". Thus, immunization at one mucosal site been associated with the generation of responses at distal mucosal regions. We have used mucosal infection with reovirus to explore basic questions of gut mucosal immunology. In this application we will extend our studies of mucosal immunology to the oral cavity. In particular, we propose to use two viral models to analyze the B and T cell responses in the oral region after various routes of immunization. We will continue our analysis of mucosal immunity using reovirus as a model. In addition, we will initiate a new direction for our laboratory by using mucosal infection with herpesvirus as a model for studies of viral-specific immunity in the oral cavity.
| Majeski, Elizabeth I; Harley, Russell A; Bellum, Stephen C et al. (2003) Differential role for T cells in the development of fibrotic lesions associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia versus Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol 28:208-17 |
| London, Lucille; Majeski, Elizabeth I; Paintlia, Manjeet Kaur et al. (2002) Respiratory reovirus 1/L induction of diffuse alveolar damage: a model of acute respiratory distress syndrome. Exp Mol Pathol 72:24-36 |
| London, Lucille; Majeski, Elizabeth I; Altman-Hamamdzic, Sanja et al. (2002) Respiratory reovirus 1/L induction of diffuse alveolar damage: pulmonary fibrosis is not modulated by corticosteroids in acute respiratory distress syndrome in mice. Clin Immunol 103:284-95 |
| Thompson, A H; McRoberts, J G; Crowe, S R et al. (1999) Optimal induction of upper respiratory tract immunity to reovirus 1/L by combined upper and lower respiratory tract inoculation. Vaccine 17:1404-15 |
