Abstract

The proposed research is designed to expand our knowledge on the neuroendocrinology of growth.
Specific aims of the research are: one - to determine the synthesis, content and release of growth hormone-releasing hormone (GHRH) and somatostatin during normal physiological conditions, two - to establish the feedback mechanisms regulating GHRH and somatostatin synthesis, content and release, three - to determine how these parameters are altered under specific physiological and pathological conditions, and four -- to evaluate the role of thyroid hormone and the adrenal and gonadal steroids in altering the pituitary response to GHRH and somatostatin. A multifaceted approach which will incorporate current techniques of molecular biology and in vitro and in vivo models is being proposed. Dr. Wehrenberg will use the opportunities provided by the RCDA to learn and develop the new techniques and then establish such approaches as routine procedures in his laboratory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Modified Research Career Development Award (K04)
Project #
1K04DK001874-01
Application #
3072566
Study Section
Endocrinology Study Section (END)
Project Start
1988-09-30
Project End
1993-12-31
Budget Start
1988-09-30
Budget End
1989-12-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Milwaukee
Department
Type
Sch Allied Health Professions
DUNS #
City
Milwaukee
State
WI
Country
United States
Zip Code
53201

  Publications

Brogan, R S; Fife, S K; Conley, L K et al. (1997) Effects of food deprivation on the GH axis: immunocytochemical and molecular analysis. Neuroendocrinology 65:129-35
Fife, S K; Brogan, R S; Giustina, A et al. (1996) Immunocytochemical and molecular analysis of the effects of glucocorticoid treatment on the hypothalamic-somatotropic axis in the rat. Neuroendocrinology 64:131-8
Giustina, A; Misitano, V; Voltz, D et al. (1995) Adrenergic and cholinergic involvement in basal and growth hormone-releasing hormone-stimulated growth hormone secretion in glucocorticoid-treated rats. Endocr Res 21:719-32
Giustina, A; Voltz, D M; Teik, J et al. (1995) Galanin counteracts the inhibitory effects of glucocorticoids on growth hormone secretion in the rat. Metabolism 44:224-7
Butkus, J A; Brogan, R S; Giustina, A et al. (1995) Changes in the growth hormone axis due to exercise training in male and female rats: secretory and molecular responses. Endocrinology 136:2664-70
Voltz, D M; Piering, A W; Magestro, M et al. (1995) Effect of GHRP-6 and GHRH on GH secretion in rats following chronic glucocorticoid treatment. Life Sci 56:491-7
Gruaz, N M; Arsenijevic, Y; Wehrenberg, W B et al. (1994) Growth hormone (GH) deprivation induced by passive immunization against rat GH-releasing factor does not disturb the course of sexual maturation and fertility in the female rat. Endocrinology 135:509-19
Locatelli, V; Grilli, R; Torsello, A et al. (1994) Growth hormone-releasing hexapeptide is a potent stimulator of growth hormone gene expression and release in the growth hormone-releasing hormone-deprived infant rat. Pediatr Res 36:169-74
Janowski, B A; Ling, N C; Giustina, A et al. (1993) Hypothalamic regulation of growth hormone secretion during food deprivation in the rat. Life Sci 52:981-7
Ndon, J A; Giustina, A; Wehrenberg, W B (1992) Hypothalamic regulation of impaired growth hormone secretion in diabetic rats. 2. Studies in spontaneously diabetic BB Worcester rats. Neuroendocrinology 55:506-11

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