Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Modified Research Career Development Award (K04)
Project #
5K04DK002319-02
Application #
2134222
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1995-02-01
Project End
2000-01-31
Budget Start
1996-03-06
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Benaroya Research Institute at Virginia Mason
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98101
Lok, Anna S F; Lai, Ching-Lung; Leung, Nancy et al. (2003) Long-term safety of lamivudine treatment in patients with chronic hepatitis B. Gastroenterology 125:1714-22
Ettinger, R A; Liu, A W; Nepom, G T et al. (2000) Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus. J Immunol 165:3232-8
Kwok, W W; Liu, A W; Novak, E J et al. (2000) HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells. J Immunol 164:4244-9
Kwok, W W; Reijonen, H; Falk, B A et al. (1999) Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition. Hum Immunol 60:619-26
Ettinger, R A; Liu, A W; Nepom, G T et al. (1998) Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus. J Immunol 161:6439-45
Doherty, D G; Penzotti, J E; Koelle, D M et al. (1998) Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR. J Immunol 161:3527-35
Ettinger, R A; Kwok, W W (1998) A peptide binding motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus. J Immunol 160:2365-73
Koelle, D M; Johnson, M L; Ekstrom, A N et al. (1997) Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201. Hum Immunol 53:195-205
Kwok, W W; Domeier, M L; Raymond, F C et al. (1996) Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J Immunol 156:2171-7
Kwok, W W; Domeier, M E; Johnson, M L et al. (1996) HLA-DQB1 codon 57 is critical for peptide binding and recognition. J Exp Med 183:1253-8

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