Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Modified Research Career Development Award (K04)
Project #
5K04HD000968-05
Application #
2194438
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Physiology
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Chen, S; Liu, X; Segaloff, D L (2000) A novel cyclic adenosine 3',5'-monophosphate-responsive element involved in the transcriptional regulation of the lutropin receptor gene in granulosa cells. Mol Endocrinol 14:1498-508
Chen, S; Shi, H; Liu, X et al. (1999) Multiple elements and protein factors coordinate the basal and cyclic adenosine 3',5'-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells. Endocrinology 140:2100-9
Rozell, T G; Davis, D P; Chai, Y et al. (1998) Association of gonadotropin receptor precursors with the protein folding chaperone calnexin. Endocrinology 139:1588-93
Abell, A N; McCormick, D J; Segaloff, D L (1998) Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs. Mol Endocrinol 12:1857-69
Davis, D P; Rozell, T G; Liu, X et al. (1997) The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction. Mol Endocrinol 11:550-62
Jaquette, J; Segaloff, D L (1997) Temperature sensitivity of some mutants of the lutropin/choriogonadotropin receptor. Endocrinology 138:85-91
Abell, A N; Segaloff, D L (1997) Evidence for the direct involvement of transmembrane region 6 of the lutropin/choriogonadotropin receptor in activating Gs. J Biol Chem 272:14586-91
Thomas, D; Rozell, T G; Liu, X et al. (1996) Mutational analyses of the extracellular domain of the full-length lutropin/choriogonadotropin receptor suggest leucine-rich repeats 1-6 are involved in hormone binding. Mol Endocrinol 10:760-8
Abell, A; Liu, X; Segaloff, D L (1996) Deletions of portions of the extracellular loops of the lutropin/choriogonadotropin receptor decrease the binding affinity for ovine luteinizing hormone, but not human choriogonadotropin, by preventing the formation of mature cell surface receptor. J Biol Chem 271:4518-27
Rozzell, T G; Wang, H; Liu, X et al. (1995) Intracellular retention of mutant gonadotropin receptors results in loss of hormone binding activity of the follitropin receptor but not of the lutropin/choriogonadotropin receptor. Mol Endocrinol 9:1727-36

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