Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL001130-02
Application #
3073650
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1984-01-01
Project End
1988-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Kuross, S A; Rank, B H; Hebbel, R P (1989) Iron compartments associated with sickle RBC membranes: a mechanism for the targeting of oxidative damage. Prog Clin Biol Res 319:601-10;discussion 611-3
Hebbel, R P; Ney, P A; Foker, W (1989) Autoxidation, dehydration, and adhesivity may be related abnormalities of sickle erythrocytes. Am J Physiol 256:C579-83
Hebbel, R P; Morgan, W T; Eaton, J W et al. (1988) Accelerated autoxidation and heme loss due to instability of sickle hemoglobin. Proc Natl Acad Sci U S A 85:237-41
Rank, B H; Moyer, N L; Hebbel, R P (1988) Vesiculation of sickle erythrocytes during thermal stress. Blood 72:1060-3
Kuross, S A; Hebbel, R P (1988) Nonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidation. Blood 72:1278-85
Kuross, S A; Rank, B H; Hebbel, R P (1988) Excess heme in sickle erythrocyte inside-out membranes: possible role in thiol oxidation. Blood 71:876-82
Hebbel, R P; Miller, W J (1988) Unique promotion of erythrophagocytosis by malondialdehyde. Am J Hematol 29:222-5
Smith 2nd, C M; Hebbel, R P; Tukey, D P et al. (1987) Pluronic F-68 reduces the endothelial adherence and improves the rheology of liganded sickle erythrocytes. Blood 69:1631-6
Hebbel, R P; Visser, M R; Goodman, J L et al. (1987) Potentiated adherence of sickle erythrocytes to endothelium infected by virus. J Clin Invest 80:1503-6
Hebbel, R P; Shalev, O; Foker, W et al. (1986) Inhibition of erythrocyte Ca2+-ATPase by activated oxygen through thiol- and lipid-dependent mechanisms. Biochim Biophys Acta 862:8-16

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