Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL001913-03
Application #
3074179
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1986-12-01
Project End
1991-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Type
School of Medicine & Dentistry
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Antone, S M; Adderson, E E; Mertens, N M et al. (1997) Molecular analysis of V gene sequences encoding cytotoxic anti-streptococcal/anti-myosin monoclonal antibody 36.2.2 that recognizes the heart cell surface protein laminin. J Immunol 159:5422-30
Quinn, A; Adderson, E E; Shackelford, P G et al. (1995) Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal monoclonal antibody recognizing streptococcal M protein and human cardiac myosin epitopes. J Immunol 154:4203-12
Gauntt, C J; Tracy, S M; Chapman, N et al. (1995) Coxsackievirus-induced chronic myocarditis in murine models. Eur Heart J 16 Suppl O:56-8
Shikhman, A R; Cunningham, M W (1994) Immunological mimicry between N-acetyl-beta-D-glucosamine and cytokeratin peptides. Evidence for a microbially driven anti-keratin antibody response. J Immunol 152:4375-87
Kil, K S; Cunningham, M W; Barnett, L A (1994) Cloning and sequence analysis of a gene encoding a 67-kilodalton myosin-cross-reactive antigen of Streptococcus pyogenes reveals its similarity with class II major histocompatibility antigens. Infect Immun 62:2440-9
Huber, S A; Moraska, A; Cunningham, M (1994) Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group A streptococci. Proc Natl Acad Sci U S A 91:5543-7
Cunningham, M W; Antone, S M; Gulizia, J M et al. (1993) Alpha-helical coiled-coil molecules: a role in autoimmunity against the heart. Clin Immunol Immunopathol 68:118-23
Huber, S; Polgar, J; Moraska, A et al. (1993) T lymphocyte responses in CVB3-induced murine myocarditis. Scand J Infect Dis Suppl 88:67-78
McCormack, J M; Crossley, C A; Ayoub, E M et al. (1993) Poststreptococcal anti-myosin antibody idiotype associated with systemic lupus erythematosus and Sjogren's syndrome. J Infect Dis 168:915-21
Shikhman, A R; Greenspan, N S; Cunningham, M W (1993) A subset of mouse monoclonal antibodies cross-reactive with cytoskeletal proteins and group A streptococcal M proteins recognizes N-acetyl-beta-D-glucosamine. J Immunol 151:3902-13

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