I have been the statistician for the Stanford Center for Research in Disease Prevention for over three years. I have participated as an author of 40 papers in established scientific journals, including: the relationships of lipoproteins to diet, exercise, weight loss, cigarette use, sex hormones, and heart rate; lipoprotein subfraction interrelationships; the statistical evaluation of community studies; and the development of new statistical methodology for studying genetic epidemiology of lipoprotein levels. I see the development of my career plans primarily in terms of the pursuit of specific research objectives: 1) to synthesize previous research on the effects of exercise on lipoprotein metabolism into a cohesive theory; 2) to evaluate methodologic approaches for describing the relationships of diet to CHD risk factors in epidemiologic surveys; and 3) to develop statistical methodology for obtaining unbiased estimates of the relationships between lipoprotein concentrations, exercise and diet when these variables are measured imprecisely due to measurement error. The Research Career Development Award would allow me to devote the time required to make progress in these areas, thereby advancing my potential as an independent investigator through concentrated studies of lipoprotein metabolism, advanced statistical analyses, and experimental design under the direction of Drs. Peter D.S. Wood, William L. Haskell, and John W Farquhar at the Standford Center for Research in Disease Prevention, and Dr. Ronald M. Krauss at the University of California at Berkeley. The Research Career Development Award is requested for the purposes of continuing my studies into the effects of exercise, weight-loss and diet on plasma lipoprotein concentrations through the statistical analyses to data collected as part of three studies on the effects of exercise and weight loss on plasma lipoprotein concentrations. The specific objective of the analyses set forth in this proposal are: 1) Develop more completely a proposed theory on the relationship of weight set-point to the elevated HDL concentrations of long-distance runners; 2) Continue my analyses of the effects of training level, weight loss, increased calorie intake, and improved fitness on serum mass concentrations of low and very-low density lipoproteins; 3) Assess the effects of measurement error on correlational analyses of changes in plasma lipoprotein concentrations in these three longitudinal studies of weight loss and exercise; 4) Assess the effects of measurement error on correlational analyses on nutrient intake and lipoprotein concentrations using the baseline data collected in the three studies; 5) Examine the correlations of intakes of calories from food groups vs. lipoprotein concentrations as an alternative to the traditional epidemiologic approach to studying diet/lipoprotein relationships with respect to nutrient intake.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL002183-04
Application #
3074346
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1989-04-01
Project End
1994-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Lawrence Berkeley National Laboratory
Department
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Williams, P T; Haskell, W L; Vranizan, K M et al. (1995) The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: the Stanford Coronary Risk Intervention Project baseline survey. Metabolism 44:106-14
Williams, P T; Dreon, D M; Krauss, R M (1995) Effects of dietary fat on high-density-lipoprotein subclasses are influenced by both apolipoprotein E isoforms and low-density-lipoprotein subclass patterns. Am J Clin Nutr 61:1234-40
Williams, P T; Austin, M A; Krauss, R M (1994) Variations in high-density lipoprotein subclasses during the menstrual cycle. Metabolism 43:1438-41
Williams, P T; Stefanick, M L; Vranizan, K M et al. (1994) The effects of weight loss by exercise or by dieting on plasma high-density lipoprotein (HDL) levels in men with low, intermediate, and normal-to-high HDL at baseline. Metabolism 43:917-24
Williams, P T; Krauss, R M; Stefanick, M L et al. (1994) Effects of low-fat diet, calorie restriction, and running on lipoprotein subfraction concentrations in moderately overweight men. Metabolism 43:655-63
Williams, P T; Vranizan, K M; Austin, M A et al. (1993) Associations of age, adiposity, alcohol intake, menstrual status, and estrogen therapy with high-density lipoprotein subclasses. Arterioscler Thromb 13:1654-61
Williams, P T; Vranizan, K M; Austin, M A et al. (1992) Familial correlations of HDL subclasses based on gradient gel electrophoresis. Arterioscler Thromb 12:1467-74
Williams, P T; Vranizan, K M; Krauss, R M (1992) Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women. J Lipid Res 33:765-74
Williams, P T; Krauss, R M; Vranizan, K M et al. (1992) Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men. Metabolism 41:441-9
Wood, P D; Stefanick, M L; Williams, P T et al. (1991) The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. N Engl J Med 325:461-6

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