RESEARCH PROPOSED: The research proposed is an excellent series of experiments to first, evaluate the role of phosphorylation in regulating the function of drosophila sodium channels, and the to determine the complement of ion channels expressed by drosophila neurons by molecular fingerprinting of PCR products from single neurons. These studies complement each other well: the studies on phosphorylation and regulation of alternately spliced domains of drosophila para sodium channels are a clear extension of the ongoing research, and utilize state-of-the-art techniques with which she is familiar, such as single- cell PCR, while the last specific aim consists of experiments that utilize less explored techniques, but could provide significant new information and provide her with data that would continue her research in the area of control of ion channel expression during development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Modified Research Career Development Award (K04)
Project #
5K04NS001854-04
Application #
2750777
Study Section
Neurology C Study Section (NEUC)
Program Officer
Leblanc, Gabrielle G
Project Start
1995-09-30
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Anatomy/Cell Biology
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697