? The overall goal of this K05 proposal is to support and extend my research in the treatment of drug abuse, especially nicotine dependence, to further my capacity to mentor junior scientists, to allow me to continue in scientific leadership and dissemination of research findings to the clinical community. My interests focus on the treatment of drug dependence, especially nicotine dependence as a chronic, relapsing disorder. I am also interested in comorbidities across drugs of abuse. I will complete two R01 grants that focus on extended treatment of cigarette smoking: (1) a study of extended behavioral relapse prevention and bupropion treatment for chronic smokers; (2) a study of extended, age-specific relapse prevention and nicotine replacement treatment for older smokers. I will continue to direct a P50 center grant that focuses on Blended Treatments for Complex Patients. My center component, Treatment of Comorbid Smokers, studies an innovative intervention for depressed smokers in a psychiatric outpatient clinic, and determines the efficacy and cost-effectiveness of the intervention. I will also complete a pilot study funded by the state of California on interventions for frail elderly smokers. In later years of this award, I will develop and propose studies that are logical extensions of ongoing work. I will continue to direct a postdoctoral training program in drug abuse treatment and services research, and participate in other research training programs, and will disseminate results to the clinical community. The award will allow me time and give me support to pursue research projects that further current work in smoking, depression, antidepressants, and psychotherapy, to spend appropriate time mentoring junior faculty, to continue my involvement in center grants and other collaborative mechanisms, and to refine my methodological skills and disseminate research findings to the professional community. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA016752-05
Application #
7242599
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2003-08-20
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
5
Fiscal Year
2007
Total Cost
$113,724
Indirect Cost
Name
University of California San Francisco
Department
Psychiatry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Gubner, Noah R; Guydish, Joseph; Humfleet, Gary L et al. (2017) Nicotine biomarkers and rate of nicotine metabolism among cigarette smokers taking buprenorphine for opioid dependency. Drug Alcohol Depend 178:267-270
Leyro, Teresa M; Crew, Erin E; Bryson, Susan W et al. (2016) Retrospective analysis of changing characteristics of treatment-seeking smokers: implications for further reducing smoking prevalence. BMJ Open 6:e010960
Schuck, Rachel K; Dahl, Audun; Hall, Sharon M et al. (2016) Smokers with serious mental illness and requests for nicotine replacement therapy post-hospitalisation. Tob Control 25:27-32
Hall, Sharon M; Shi, Yanling; Humfleet, Gary L et al. (2015) Smoking cessation abstinence goal in treatment-seeking smokers. Addict Behav 42:148-53
Leyro, Teresa M; Hendricks, Peter S; Hall, Sharon M (2015) If at first you don't succeed: characterization of smokers with late smoking abstinence onset. Addict Behav 45:34-8
Benowitz, Neal L; Nardone, Natalie; Dains, Katherine M et al. (2015) Effect of reducing the nicotine content of cigarettes on cigarette smoking behavior and tobacco smoke toxicant exposure: 2-year follow up. Addiction 110:1667-75
Barnett, Paul G; Wong, Wynnie; Jeffers, Abra et al. (2015) Cost-effectiveness of smoking cessation treatment initiated during psychiatric hospitalization: analysis from a randomized, controlled trial. J Clin Psychiatry 76:e1285-91
Grady, Eric S; Humfleet, Gary L; Delucchi, Kevin L et al. (2014) Smoking cessation outcomes among sexual and gender minority and nonminority smokers in extended smoking treatments. Nicotine Tob Res 16:1207-15
Bergen, Andrew W; Javitz, Harold S; Krasnow, Ruth et al. (2014) Organic cation transporter variation and response to smoking cessation therapies. Nicotine Tob Res 16:1638-46
Young-Wolff, Kelly C; Fromont, Sebastien C; Delucchi, Kevin et al. (2014) PTSD symptomatology and readiness to quit smoking among women with serious mental illness. Addict Behav 39:1231-4

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