A competing continuation of a Senior Scientist Award (formerly Research Scientist Award) is requested. The main focus is the study of the neurobiology and treatment of anxiety disorders, particularly panic. The candidate has held three successive five-year """"""""K"""""""" award grants from NIMH. Four main areas of research are proposed: 1) studies of respiratory physiology in PD; 2) the relationships among respiratory, noradrenergic, and serotonergic function in PD; 3) developmental aspects of anxiety disorder including a preclinical model of anxiety, studies of anxious children, and development of a geriatric anxiety program; and 4) the role of CNS innervation in the cardiovascular response to acute and chronic stress. A hypothetical model is presented that will guide the candidate in studies attempting to elucidated biological aspects of PD and their relationship to cognitive and behavioral aspects. This includes placing respiratory abnormalities in panic in their proper perspective, testing relationships among several brain systems in the pathogenesis of panic, and studying the effects of early life traumatic stress on the biological and behavioral predisposition to anxiety disorder. Work on the """"""""heart-brain"""""""" interaction includes studying heart transplant patients as a model of cardiac denervation in order to isolate the precise mechanisms by which the CNS controls cardiovascular function. In this proposed continuation period, particular attention will be placed on training in several neuroimaging techniques. Pilot single photon emission computerized tomography (SPECT) and positron emission tomography (PET) studies are described and plans for the use of functional magnetic resonance imaging to study carbon dioxide (C02) responsive zones of brain are also planned.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
2K05MH000416-16
Application #
2379124
Study Section
Clinical Neuroscience and Biological Psychopathology Review Committee (CNBP)
Project Start
1987-09-01
Project End
2002-04-30
Budget Start
1997-09-01
Budget End
1998-04-30
Support Year
16
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Mathew, S J; Coplan, J D; Gorman, J M (2001) Management of treatment-refractory panic disorder. Psychopharmacol Bull 35:97-110