This proposal seeks support for a Research Scientist Award (KO5) to allow the candidate to continue full-time involvement in an comprehensive program of research in Psychiatric Genetics that he has been developing since 1983. This research program is supported by the following projects, on which the candidate is Principal Investigator: 1) the Irish High Density Schizophrenia Study, research involving a sample of over 270 schizophrenia multiplex families systematically ascertained from the entire island of Ireland, with the goal of detecting susceptibility loci for schizophrenia by linkage analysis; 2) the Roscommon Family Study, a large-sample, controlled, epidemiologic family study of schizophrenia and other major mental disorders based in the West of Ireland, the goal of which is to understand the familial determinants of schizophrenia and schizophrenia spectrum disorders; 3) the Female Twin-Family Virginia Twin Study, a sample of 1,033 longitudinally followed female-female twin pairs ascertained from the population-based Virginia Twin Registry and their parents, with the goal of understanding the role of genetic and environmental risk factors in the etiology of common psychiatric disorders and alcoholism in women and 4) the Male Virginia Twin Study, which is an on-going longitudinal study of 1,500 male-male and 1,300 male-female twin pairs, also from the Virginia Twin Registry. The goal of this final project is to clarify the genetic and environmental risk factors for the common psychiatric and substance use disorders in men and to understand the relationship between these factors and the risk factors that influence the vulnerability to these disorders in women. The candidate has been active in training Post-doctoral fellows and younger faculty for research careers in psychiatric genetics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
5K05MH001277-03
Application #
2032853
Study Section
Epidemiology and Genetics Review Committee (EPI)
Project Start
1995-01-01
Project End
1999-12-31
Budget Start
1997-01-01
Budget End
1997-12-31
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Jacobson, Kristen C; Prescott, Carol A; Kendler, Kenneth S (2002) Sex differences in the genetic and environmental influences on the development of antisocial behavior. Dev Psychopathol 14:395-416
Kendler, K S; Thornton, L M; Gardner, C O (2001) Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. Am J Psychiatry 158:582-6
Sullivan, P F; O'Neill, F A; Walsh, D et al. (2001) Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families. Am J Med Genet 105:266-70
Hettema, J M; Prescott, C A; Kendler, K S (2001) A population-based twin study of generalized anxiety disorder in men and women. J Nerv Ment Dis 189:413-20
Kendler, K S (2001) Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 58:1005-14
Goldstein, R B; Prescott, C A; Kendler, K S (2001) Genetic and environemental factors in conduct problems and adult antisocial behavior among adult female twins. J Nerv Ment Dis 189:201-9
Kendler, K S; Thornton, L M; Prescott, C A (2001) Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects. Am J Psychiatry 158:587-93
Kendler, K S; Gardner, C O; Neale, M C et al. (2001) Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychol Med 31:605-16
Kendler, K S; Aggen, S H (2001) Time, memory and the heritability of major depression. Psychol Med 31:923-8
Kendler, K S; Gardner, C O; Prescott, C A (2001) Are there sex differences in the reliability of a lifetime history of major depression and its predictors? Psychol Med 31:617-25

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