The purpose of the research outlined in the Research Scientist Award is to investigate the neurobiology of schizophrenia by integrating clinical, neurobehavioral, neuroanatomic and neurophysiologic measures of brain function. In the clinical domain, symptoms and functioning will be evaluated longitudinally. A lifespan perspective of schizophrenia, from new onset patients to the elderly, will enable examination of the disease process and establish a prospective brain collection for antemortem- postmortem correlations. Gender differences and vulnerability will be assessed from a neuropsychiatric perspective. The neurobehavioral measures will evaluate major cognitive and affective computational domains related to regional brain function. Neuroanatomic parameters will be obtained with magnetic resonance imaging (MRI) volumetric measurements and with postmortem neuropathologic studies. Neurophysiologic parameters will consist of cerebral blood flow (CBF) and glucose metabolism measured with positron emission tomography (PET) and neuroreceptor density and affinity will be measured with PET and with single-photon emission computed tomography (SPECT), as well as postmortem receptor autoradiography. It is proposed to further develop and apply magnetic resonance spectroscopy (MRS) to examine biochemical parameters and magnetic resonance flow (MRF) to evaluate CBF related changes. The integration will be achieved through the use of """"""""neurobehavioral"""""""" and pharmacologic probes that permit testing hypotheses on brain behavior relation as a function of clinical profile.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
1K05MH001336-01
Application #
2240981
Study Section
Special Emphasis Panel (SRCM (02))
Project Start
1995-09-15
Project End
2000-08-31
Budget Start
1995-09-15
Budget End
1996-08-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kurtz, Matthew M; Moberg, Paul J; Ragland, J Daniel et al. (2005) Symptoms versus neurocognitive test performance as predictors of psychosocial status in schizophrenia: a 1- and 4-year prospective study. Schizophr Bull 31:167-74
Kurtz, Matthew M; Ragland, J Daniel; Moberg, Paul J et al. (2004) The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms of repeat administration. Arch Clin Neuropsychol 19:191-201
Gur, R C; Ragland, J D; Moberg, P J et al. (2001) Computerized neurocognitive scanning: I. Methodology and validation in healthy people. Neuropsychopharmacology 25:766-76
Kurtz, M M; Moberg, P J; Mozley, L H et al. (2001) Effectiveness of an attention- and memory-training program on neuropsychological deficits in schizophrenia. Neurorehabil Neural Repair 15:75-80
Kurtz, M M; Ragland, J D; Bilker, W et al. (2001) Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia. Schizophr Res 48:307-16
Gur, R C; Ragland, J D; Moberg, P J et al. (2001) Computerized neurocognitive scanning: II. The profile of schizophrenia. Neuropsychopharmacology 25:777-88
Gur, R E; Turetsky, B I; Cowell, P E et al. (2000) Temporolimbic volume reductions in schizophrenia. Arch Gen Psychiatry 57:769-75
Kohler, C G; Bilker, W; Hagendoorn, M et al. (2000) Emotion recognition deficit in schizophrenia: association with symptomatology and cognition. Biol Psychiatry 48:127-36
Matsui, M; Gur, R C; Turetsky, B I et al. (2000) The relation between tendency for psychopathology and reduced frontal brain volume in healthy people. Neuropsychiatry Neuropsychol Behav Neurol 13:155-62
Gur, R C; Turetsky, B I; Matsui, M et al. (1999) Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance. J Neurosci 19:4065-72

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