Abstract

This application requests support to develop an Multi-institutional Center on the Comparative Biology of Aging in San Antonio. The comparative study of the biology of aging is an emerging experimental paradigm that promises to increase our understanding of the basic processes of aging. No single institution has all the elements needed to build such a center. However, by combining the strengths of three institutions a world-class center can be developed. This center will incorporate the strengths in gerontological research of The University of Texas Health Science Center at San Antonio (UTHSCSA) and will build and expand upon the established strengths of the Southwest National Primate Research Center in primate research and the University of Texas at San Antonio in biology and neuroscience. The development of this center will be accomplished by the collaboration of the three institutions to facilitate the recruitment of faculty with interests in this area, establish an annual pilot project program, develop a new inter-institutional course in the Comparative Biology of Aging and sponsor an Annual Workshop on the Comparative Biology of Aging. In addition, research seminar programs at all three institutions will host a substantial number of seminars to this area. The development of this new program will strengthen aging research at the University of Texas at San Antonio and at the Southwest Foundation for Biomedical Research and at the same time, will contribute substantially to the national research enterprise in aging. The structure of the proposed program will guarantee optimal integration with established research programs at each of the Institutions. The value of such a Center to the advancement of our understanding of the basic mechanisms of aging has recently become clear and the breath and depth of research into the Biology of Aging in San Antonio makes this a logical home for an effective Center on the Comparative Biology of Aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07AG025063-03
Application #
7099526
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Williams, John
Project Start
2004-09-30
Project End
2009-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
3
Fiscal Year
2006
Total Cost
$108,000
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Pathology
Type
Other Domestic Higher Education
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Ungvari, Zoltan; Csiszar, Anna; Sosnowska, Danuta et al. (2013) Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). J Gerontol A Biol Sci Med Sci 68:359-67
Ungvari, Zoltan; Sosnowska, Danuta; Mason, Jeffrey B et al. (2013) Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype? J Gerontol A Biol Sci Med Sci 68:521-9
De Waal, Eric M; Liang, Hanyu; Pierce, Anson et al. (2013) Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: a proteomic approach. Biochem Biophys Res Commun 434:815-9
Csiszar, Anna; Podlutsky, Andrej; Podlutskaya, Natalia et al. (2012) Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci 67:841-52
Ungvari, Zoltan; Ridgway, Iain; Philipp, Eva E R et al. (2011) Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal. J Gerontol A Biol Sci Med Sci 66:741-50
Austad, Steven N (2011) Candidate bird species for use in aging research. ILAR J 52:89-96
Fischer, Kathleen E; Austad, Steven N (2011) The development of small primate models for aging research. ILAR J 52:78-88
Bhattacharya, Arunabh; Leonard, Shanique; Tardif, Suzette et al. (2011) Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant? Aging Cell 10:720-3
Austad, Steven N (2010) Cats, ""rats,"" and bats: the comparative biology of aging in the 21st century. Integr Comp Biol 50:783-92
Valdez, Chris M; Smith, Mark A; Perry, George et al. (2010) Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers. Hippocampus 20:902-5

Showing the most recent 10 out of 15 publications