) This proposal seeks five years of funding to develop research and teaching skills in cancer epidemiology and to undertake laboratory training in molecular pathology methods which can be applied to cancer epidemiology studies. I have recently finished a joint M.D.-Ph.D. degree from the University of Iowa, with a Ph.D. degree in epidemiology. I have completed postdoctoral training in cancer epidemiology at the University of Minnesota and in Aging at the University of Iowa. I am currently an Assistant Professor of Epidemiology, tenure track, in the Department of Preventive Medicine and Environmental Health at the University of Iowa. The goal of my research plan is to acquire new skills in molecular pathology and clinical immunology which can be applied to my cancer epidemiology studies. I will focus my attention on the possible role of blood transfusions in the carcinogenic process. With this grant, I will attempt to replicate and expand my work on prior blood transfusion as a cancer risk factor by analyzing three previously collected case-control studies and an ongoing prospective cohort study. I also plan to develop a nested case-control study assessing transfusion history and lymphoma risk using the Agricultural Health Study cohort. In order to assess whether any transfusion and cancer risk association is confounded by the indication for the transfusion, I will conduct a pilot study of battle-injured Vietnam veterans which will lay the groundwork for studying whether blood transfusion for a non-specific- indication (i.e., trauma) is related to cancer risk. In order to address potential mechanisms underlying the putative association, I will use molecular pathology techniques to study whether the Epstein-Barr virus has an etiologic role in the transfusion and lymphoma association and whether Cytomegalovirus has an etiologic role in the transfusion and kidney cancer association. I will also design and conduct a pilot study to assess the immunological consequences that a blood transfusion has for an immunocompetent host. My other professional goals during this grant include the development of teaching skills in cancer epidemiology and experience in helping manage a cancer registry. To accomplish these goals, I will work in consultation with senior faculty members from the Departments of Preventive Medicine and Environmental Health, Pathology, and Internal Medicine and from the Cancer Center at the University of Iowa.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07CA064220-02
Application #
2443089
Study Section
Cancer Research Manpower and Education Review Committee (CRME)
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Iowa
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Cerhan, James R; Engels, Eric A; Cozen, Wendy et al. (2008) Blood transfusion, anesthesia, surgery and risk of non-Hodgkin lymphoma in a population-based case-control study. Int J Cancer 123:888-94
Narla, Goutham; Difeo, Analisa; Reeves, Helen L et al. (2005) A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Res 65:1213-22
Pavuk, Marian; Cerhan, James R; Lynch, Charles F et al. (2004) Environmental exposure to PCBs and cancer incidence in eastern Slovakia. Chemosphere 54:1509-20
Cerhan, James R; Grabrick, Dawn M; Vierkant, Robert A et al. (2004) Interaction of adolescent anthropometric characteristics and family history on breast cancer risk in a Historical Cohort Study of 426 families (USA). Cancer Causes Control 15:1-9
Cerhan, James R; Potter, John D; Gilmore, Julie M E et al. (2004) Adherence to the AICR cancer prevention recommendations and subsequent morbidity and mortality in the Iowa Women's Health Study cohort. Cancer Epidemiol Biomarkers Prev 13:1114-20
Elkins, David A; Yokomizo, Akira; Thibodeau, Stephen N et al. (2003) Luteinizing hormone beta polymorphism and risk of familial and sporadic prostate cancer. Prostate 56:30-6
Cerhan, James R; Anderson, Kristin E; Janney, Carol A et al. (2003) Association of aspirin and other non-steroidal anti-inflammatory drug use with incidence of non-Hodgkin lymphoma. Int J Cancer 106:784-8
Pavuk, Marian; Cerhan, James R; Lynch, Charles F et al. (2003) Case-control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia. J Expo Anal Environ Epidemiol 13:267-75
Schroeder, J C; Olshan, A F; Baric, R et al. (2002) A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States). Cancer Causes Control 13:159-68
Sellers, Thomas A; Vierkant, Robert A; Cerhan, James R et al. (2002) Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women. Cancer Epidemiol Biomarkers Prev 11:1104-7

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