) Candidate: Stephanie Smith-Warner received her doctoral degree in epidemiology, with a focus on nutritional epidemiology, from the University of Minnesota. She has been involved with the conduct of several types of epidemiologic studies and has experience in the areas of study design, questionnaire development, data management and data analysis. Dr. Smith-Warner is interested in strengthening her research background and development as an independent researcher in the fields of cancer epidemiology and nutritional epidemiology. Environment: Dr. David J. Hunter, the current Project Leader of the Pooling Project, has agreed to be the sponsor for this proposal. Dr. Hunter has extensive experience in mentoring graduate students and postdoctoral fellows in diverse areas of study. In addition, the Principal Investigators of the individual studies included in the Pooling Project are enthusiastic about expanding their collaboration to evaluate diet and lung cancer associations. Finally, faculty in the Nutrition Department at the Harvard School of Public Health actively collaborate with scientists in other departments and institutions. This multifaceted, collaborative environment provides unique opportunities for furthering Dr. Smith-Warner's research training. Research Proposal: This proposal builds upon the existing Pooling Project of Prospective Studies and Cancer to evaluate associations between diet and lung cancer, a leading cause of mortality worldwide. Pooling data from multiple studies will permit more precise estimation of the associations and more standardized categorization of exposures and covariates. From the eight studies comprising the Pooling Project for these analyses, approximately 1,753 female and 1,945 male lung cancer cases were ascertained prospectively. The association between lung cancer and fruits and vegetables will be evaluated to determine whether specific fruits and vegetables, rather than total consumption, are most strongly related to lung cancer risk. Due to the recent controversy surrounding the association between B-carotene and lung cancer, the relationship with individual carotenoids will be assessed. Relationships with vitamins A, C and E, fat, cholesterol and alcohol also will be evaluated. A methods development aim is to use new analyses of diet diversity and diet indices to examine the effects of total diet, rather than individual components. For each exposure effect modification by smoking status and gender will be examined. These analyses will take full advantage of extensive data already collected in the individual cohorts to provide a powerful analysis of the relation between diet and lung cancer.
| Mannisto, Satu; Yaun, Shiaw-Shyuan; Hunter, David J et al. (2007) Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies. Am J Epidemiol 165:246-55 |
| Cho, Eunyoung; Hunter, David J; Spiegelman, Donna et al. (2006) Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies. Int J Cancer 118:970-8 |
| Smith-Warner, Stephanie A; Spiegelman, Donna; Ritz, John et al. (2006) Methods for pooling results of epidemiologic studies: the Pooling Project of Prospective Studies of Diet and Cancer. Am J Epidemiol 163:1053-64 |
| Freudenheim, Jo L; Ritz, John; Smith-Warner, Stephanie A et al. (2005) Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies. Am J Clin Nutr 82:657-67 |
| Park, Yikyung; Hunter, David J; Spiegelman, Donna et al. (2005) Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies. JAMA 294:2849-57 |
| Mannisto, Satu; Smith-Warner, Stephanie A; Spiegelman, Donna et al. (2004) Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev 13:40-8 |
| Cho, Eunyoung; Smith-Warner, Stephanie A; Ritz, John et al. (2004) Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. Ann Intern Med 140:603-13 |
| Cho, Eunyoung; Smith-Warner, Stephanie A; Spiegelman, Donna et al. (2004) Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies. J Natl Cancer Inst 96:1015-22 |
| Smith-Warner, Stephanie A; Spiegelman, Donna; Yaun, Shiaw-Shyuan et al. (2003) Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. Int J Cancer 107:1001-11 |
| Smith-Warner, Stephanie A; Ritz, John; Hunter, David J et al. (2002) Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. Cancer Epidemiol Biomarkers Prev 11:987-92 |
