Dr. Smith-Bindman is an Assistant Professor in Radiology, and recently completed a two year fellowship in epidemiology, biostatistics, and research design sponsored jointly by the Departments of Epidemiology and Biostatistics and the General Internal Medicine Section, University of California, San Francisco. Her broad research interest is in performing outcome assessment of diagnostic imaging tests in areas targeted to women's health. Specifically her research interest is in evaluating the outcomes of performing mammographic screening in elderly women. A more thorough understanding of the relationship between screening mammography, breast cancer detection and treatment, and breast cancer mortality is critical to the planning of public policy regarding who should undergo mammographic screening. The proposed study involves the design and implementation of a data analysis of California Health Care Financing Administration Medicare billing claims that have been linked with tumor registry data from the California Cancer Registry on breast cancer stage and treatment. The data will be analyzed at the California Medical Review Incorporated, a Medicare quality improvement organization. Similar data has been successfully analyzed by this investigator previously.
The specific aims will focus on the outcome of performing screening mammography in women older than age 65 years. The proposal will evaluate the following: 1) differences in breast cancer mortality, 2) differences in breast cancer treatment rates including mastectomy, lumpectomy and radiation and 3) difference in breast cancer tumor attributes including size and stage between women who were previously screened with mammography and women who were not. She will also evaluate if women with co-morbidities have different outcomes from undergoing screening as women without co-morbidities. For the training component of the award, she will take additional course work in biostatistical methods to develop expertise in adjustment for confounding, and she will meet regularly with her sponsors. Dr. Smith-Bindman has assembled a multidisciplinary team of nationally recognized clinical researchers. They are enthusiastic about her research plan and are dedicated to assisting her in developing outstanding research skills and successfully completing the planned research. The Career Development Award will provide five years of supervised experience to enable Dr. Smith-Bindman to become an independent investigator in the area of mammographic screening in elderly women.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07CA086032-02
Application #
6174416
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Gorelic, Lester S
Project Start
1999-09-30
Project End
2004-09-29
Budget Start
2000-09-30
Budget End
2001-09-29
Support Year
2
Fiscal Year
2000
Total Cost
$127,170
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Venkatesan, Aruna; Chu, Philip; Kerlikowske, Karla et al. (2009) Positive predictive value of specific mammographic findings according to reader and patient variables. Radiology 250:648-57
Goldman, L Elizabeth; Haneuse, Sebastien J-P A; Miglioretti, Diana L et al. (2008) An assessment of the quality of mammography care at facilities treating medically vulnerable populations. Med Care 46:701-8
Tice, Jeffrey A; Cummings, Steven R; Smith-Bindman, Rebecca et al. (2008) Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model. Ann Intern Med 148:337-47
Curtis, Elana; Quale, Chris; Haggstrom, David et al. (2008) Racial and ethnic differences in breast cancer survival: how much is explained by screening, tumor severity, biology, treatment, comorbidities, and demographics? Cancer 112:171-80
Smith-Bindman, Rebecca; Quale, Chris; Chu, Philip W et al. (2006) Can Medicare billing claims data be used to assess mammography utilization among women ages 65 and older? Med Care 44:463-70
Kagay, Christopher R; Quale, Christopher; Smith-Bindman, Rebecca (2006) Screening mammography in the American elderly. Am J Prev Med 31:142-9
Smith-Bindman, Rebecca; Miglioretti, Diana L; Lurie, Nicole et al. (2006) Does utilization of screening mammography explain racial and ethnic differences in breast cancer? Ann Intern Med 144:541-53
Sickles, Edward A; Miglioretti, Diana L; Ballard-Barbash, Rachel et al. (2005) Performance benchmarks for diagnostic mammography. Radiology 235:775-90
Smith-Bindman, Rebecca; Ballard-Barbash, Rachel; Miglioretti, Diana L et al. (2005) Comparing the performance of mammography screening in the USA and the UK. J Med Screen 12:50-4
Haggstrom, David A; Quale, Chris; Smith-Bindman, Rebecca (2005) Differences in the quality of breast cancer care among vulnerable populations. Cancer 104:2347-58

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