The proposed Career Development Award will help Dr. Susan McCami gain independence in a career focused on the nutritional epidemiology of chronic disease, integrating her background in nutritional sciences and epidemiology, and gaining new expertise in molecular epidemiology. Her immediate goals as outlined below include an investigation of tho relationship between food components with hormonal activities (phytoestrogens) and breast cancer risk using retrospective and experimental designs and to collaborate with ongoing research in the Department of Social and Preventive Medicine (SPM). SPM has a long history of research in diet and cancer and is ideally suited for this research. In addition, she will receive training and insight into the integration of laboratory methods into epidemiology and the inclusion of genetic susceptibility in epidemiologic studies, and further training in onclogy, molecular epidemiology, and endocrinology. Proposed here are two studies examining the role of dietary phytoestrogens in the etiology of pre- and postmenopausal breast cancer. The first utilizes data from a large case-control study for which data collection is currently ongoing (ending Spring 2001). Analyses will examine rite relationship between dietary intakes of lignans (major phytoestrogen source) on breast cancer risk. Data from the controls will be utilized to examine the relationship between dietary lignan intake and other dietary, non-dietary, and biomarkers of nutrition and chronic disease risk factors. Finally, we will examine genetic susceptibility as a modifying factor on these relationships by estimating risk stratified by polymorphisms of genes related to estrogen metabolism, CYP 17 and COMT. The second study involves collection of new data investigating the effect of dietary lignan supplementation on serum estrogen and phytoestrogen levels, and the impact of CYP17 and COMT polymorphisms on this relationship. Subjects in the study will consume flaxseed supplements for seven days and differences between baseline and postsupplementation serum estrogen and phytoestrogen levels assessed. These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Academic/Teacher Award (ATA) (K07)
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Study Section
Subcommittee G - Education (NCI)
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Gorelic, Lester S
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State University of New York at Buffalo
Public Health & Prev Medicine
Schools of Medicine
United States
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McCann, Susan E; McCann, William E; Hong, Chi-Chen et al. (2007) Dietary patterns related to glycemic index and load and risk of premenopausal and postmenopausal breast cancer in the Western New York Exposure and Breast Cancer Study. Am J Clin Nutr 86:465-71
McCann, Susan E; Kulkarni, Swati; Trevisan, Maurizio et al. (2006) Dietary lignan intakes and risk of breast cancer by tumor estrogen receptor status. Breast Cancer Res Treat 99:309-11
Odunsi, Kunle; Wollman, Robert M; Ambrosone, Christine B et al. (2005) Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics. Int J Cancer 113:782-8
Fuhrman, Barbara; Barba, Maddalena; Schunemann, Holger J et al. (2005) Basal growth hormone concentrations in blood and the risk for prostate cancer: a case-control study. Prostate 64:109-15
McCann, Susan E; Muti, Paola; Vito, Dominica et al. (2004) Dietary lignan intakes and risk of pre- and postmenopausal breast cancer. Int J Cancer 111:440-3
McCann, Susan E; Ip, Clement; Ip, Margot M et al. (2004) Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study). Cancer Epidemiol Biomarkers Prev 13:1480-4
McCann, S E; Sempos, C; Freudenheim, J L et al. (2003) Alcoholic beverage preference and characteristics of drinkers and nondrinkers in western New York (United States). Nutr Metab Cardiovasc Dis 13:2-11
McCann, Susan E; Freudenheim, Jo L; Marshall, James R et al. (2003) Risk of human ovarian cancer is related to dietary intake of selected nutrients, phytochemicals and food groups. J Nutr 133:1937-42
McCann, Susan E; Moysich, Kirsten B; Freudenheim, Jo L et al. (2002) The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. J Nutr 132:3036-41