This K award proposal encompasses training and research experiences designed to allow Dr. Rundle to develop into an independent researcher focusing on physical activity, and cancer epidemiology. The training component includes mentored work in physical activity and lifestyle risk factor epidemiology, lung cancer epidemiology, clinical aspects of lung cancer, and the use of biomarkers as intermediate endpoints. In addition, the plan includes biostatistics coursework, participation in seminar series and conferences, and trips to receive training at other institutions doing physical activity research. The proposed research includes a case-control study that will investigate whether physical activity, is protective against lung cancer, and a cross-sectional study that uses biomarkers as intermediate endpoints to investigate the mechanisms by which physical activity may act. The case-control study will follow up on cohort and case-control studies that have shown a protective effect of physical activity on lung cancer development and has the strength of more in depth life-time measures of physical activity and smoking habits. Furthermore, the study will be the first to control for diet as a potential confounder. Of particular interest is the affect of physical activity after smoking cessation and whether this has a protective effect. The biomarker study responds to calls for biomarker studies that can help to elucidate the protective mechanisms of physical activity. Such studies may provide biological support for observed associations with cancer, and will contribute information to determine the type, frequency, and duration of exercise needed for maximum protection. The study will determine whether physical activity is associated with increased levels of glutathione and extracellular glutathione peroxidase, and whether in turn these markers are associated with lower levels of PAH-DNA adducts and oxidative damage. Both projects are directed at the development of new lung cancer prevention programs that can supplement current smoking prevention and cessation programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Academic/Teacher Award (ATA) (K07)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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Rundle, Andrew; Richie, John; Steindorf, Karen et al. (2010) Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. Biomarkers 15:20-30
Rundle, Andrew; Richards, Catherine; Tang, Deliang et al. (2008) Lack of association between physical activity in smokers and plasma glutathione peroxidase levels. Cancer Epidemiol Biomarkers Prev 17:1004-6
Schmitz, Kathryn H; Warren, Meghan; Rundle, Andrew G et al. (2008) Exercise effect on oxidative stress is independent of change in estrogen metabolism. Cancer Epidemiol Biomarkers Prev 17:220-3
Rundle, Andrew; Hagins, Marshall; Orjuela, Manuela et al. (2007) Traditional physical activity indexes derived from the Harvard alumni activity survey have low construct validity in a lower income, urban population. J Urban Health 84:722-32
Rundle, A; Madsen, A; Orjuela, M et al. (2007) The association between benzo[a]pyrene-DNA adducts and body mass index, calorie intake and physical activity. Biomarkers 12:123-32
Rundle, Andrew; Roux, Ana V Diez; Free, Lance M et al. (2007) The urban built environment and obesity in New York City: a multilevel analysis. Am J Health Promot 21:326-34
Rundle, Andrew (2006) Carcinogen-DNA adducts as a biomarker for cancer risk. Mutat Res 600:23-36
Rundle, Andrew G; Vineis, Paolo; Ahsan, Habibul (2005) Design options for molecular epidemiology research within cohort studies. Cancer Epidemiol Biomarkers Prev 14:1899-907
Rundle, A G; Orjuela, M; Mooney, L et al. (2005) Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. Biomarkers 10:390-400
Rundle, Andrew (2005) Molecular epidemiology of physical activity and cancer. Cancer Epidemiol Biomarkers Prev 14:227-36

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