CANDIDATE - I am a pulmonologist and health outcomes researcher with a focus on lung cancer control and prevention. While I have already received my MD and MPH degrees, completed a fellowship in outcomes research, and have received funding as a Co-PI on a VA HSR&D grant to study resource utilization in evaluation of potentially cancerous pulmonary nodules, I will require further training and dedicated mentorship to achieve my career goal of becoming a leading investigator in lung cancer control. INSTITUTION - The Dartmouth Institute for Health Policy and Clinical Practice, Center for Shared Decision- Making, Norris Cotton Cancer Center, and VA Outcomes Group offer the resources to succeed in my research. PROJECT BACKGROUND - With rising use of CT scans, physicians are faced with an increasingly common diagnostic challenge - the incidental pulmonary nodule. The fear is that the nodule may be cancer. In reality, very few turn out to be malignant, but identifying this subset is difficult and involves significant trade-offs. There are no randomized trials comparing management strategies (e.g., biopsy, radiologic surveillance, no further work-up) and no literature characterizing the impact of pulmonary nodules on patients and doctors. PROJECT OBJECTIVES - To systematically study the impact on patients and physicians of diagnosing pulmonary nodules, and to use this information to develop and test a decision aid to improve knowledge about nodules and promote shared decision-making. The project has 3 specific aims:
Aim I : Characterize patients'understanding of and experience with pulmonary nodules. To determine patients'beliefs about pulmonary nodules (including lung cancer risk perception) and experience (including anxiety) with management strategies, I will develop, validate, and conduct a large-scale patient survey. -Aim II: Characterize physicians'beliefs about and management of pulmonary nodules. To learn how physicians manage, discuss, and think about pulmonary nodules (including risk of lung cancer), I will develop and conduct a nationally representative survey of primary care and pulmonary physicians. -Aim III: Develop a decision aid to improve clinical care and to use in a future randomized trial. Synthesizing the findings of Aims I and II with the evidence on pulmonary nodule natural history and management, I will create and test a decision aid for patients with pulmonary nodules. I will use the decision aid to achieve informed consent in a subsequent randomized comparative effectiveness trial of management strategies. CAREER GOALS - To become a leading independent investigator in cancer control and prevention, focusing on pulmonary nodules and lung cancer outcomes. My mentorship team includes experts in survey research, risk communication, medical decision-making, radiology, pulmonology, and oncology to help me achieve my project goals and guide me in my career development. Courses in psychometrics, decision-making, statistics, cancer control, and grant-writing will provide me with key skills for this project and my career.

Public Health Relevance

Pulmonary nodules create a huge burden on the healthcare system, and patients and physicians may have significant misconceptions about their natural history and management. Research on patient and physician views on pulmonary nodules, as well as tools to promote shared decision-making around nodule management should be a priority to improve knowledge, quality of life, and care of these patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07CA138772-05
Application #
8319530
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2009-09-21
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$169,236
Indirect Cost
$12,536
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Mehter, Hashim M; McCannon, Jessica B; Clark, Jack A et al. (2018) Physician Approaches to Conflict with Families Surrounding End-of-Life Decision-making in the Intensive Care Unit. A Qualitative Study. Ann Am Thorac Soc 15:241-249
Slatore, Christopher G; Wiener, Renda Soylemez (2018) Pulmonary Nodules: A Small Problem for Many, Severe Distress for Some, and How to Communicate About It. Chest 153:1004-1015
Iaccarino, Jonathan M; Simmons, James; Gould, Michael K et al. (2017) Clinical Equipoise and Shared Decision-making in Pulmonary Nodule Management. A Survey of American Thoracic Society Clinicians. Ann Am Thorac Soc 14:968-975
Stevenson, Elizabeth K; Mehter, Hashim M; Walkey, Allan J et al. (2017) Association between Do Not Resuscitate/Do Not Intubate Status and Resident Physician Decision-making. A National Survey. Ann Am Thorac Soc 14:536-542
Walkey, Allan J; Weinberg, Janice; Wiener, Renda Soylemez et al. (2016) Association of Do-Not-Resuscitate Orders and Hospital Mortality Rate Among Patients With Pneumonia. JAMA Intern Med 176:97-104
Simmons, James; Gould, Michael K; Iaccarino, Jonathan et al. (2016) Systems-Level Resources for Pulmonary Nodule Evaluation in the United States: A National Survey. Am J Respir Crit Care Med 193:1063-5
Freiman, Marc R; Clark, Jack A; Slatore, Christopher G et al. (2016) Patients' Knowledge, Beliefs, and Distress Associated with Detection and Evaluation of Incidental Pulmonary Nodules for Cancer: Results from a Multicenter Survey. J Thorac Oncol 11:700-708
Wiener, Renda Soylemez; Gould, Michael K; Woloshin, Steven et al. (2015) 'The thing is not knowing': patients' perspectives on surveillance of an indeterminate pulmonary nodule. Health Expect 18:355-65
Mehta, Anuj B; Syeda, Sohera N; Bajpayee, Lisa et al. (2015) Trends in Tracheostomy for Mechanically Ventilated Patients in the United States, 1993-2012. Am J Respir Crit Care Med 192:446-54
Tukey, Melissa H; Borzecki, Ann M; Wiener, Renda Soylemez (2015) Validity of ICD-9-CM codes for the identification of complications related to central venous catheterization. Am J Med Qual 30:52-7

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