This NCI K07 career development award application is designed to provide the applicant, Darren Mays, PhD, MPH, with the mentored experiences needed to become an independent investigator with expertise in behavioral tobacco control science relevant to tobacco regulatory policy. The proposed training and research activities are guided by a biobehavioral framework for tobacco-associated cancers and tobacco policy evaluation and will position me to gain new expertise in cross-cutting areas related to nicotine addiction, smoking cessation, and tobacco regulation. My career development will be guided by mentors with expertise in biobehavioral cancer and tobacco control science (Kenneth Tercyak, PhD; Raymond Niaura, PhD) and informed by an interdisciplinary team of expert consultants. Training activities will include didactic and applied skills components available through the unique resources of Georgetown University Medical Center, Georgetown Lombardi Comprehensive Cancer Center, Legacy's Schroeder Institute, and other local academic research institutions. The proposed research complements these career development activities by investigating the impact of graphic cigarette warning labels and plain (i.e., unbranded) cigarette packaging among young adult smokers ages 18-30. The 2009 Family Smoking Prevention and Tobacco Control Act was a critical step in U.S. tobacco control policy, requiring new graphic health warning labels to replace existing text-only warnings on cigarette packs. The Act also provides the framework to implement additional regulations on cigarette pack branding if evidence supports their use. Young adult smokers are a high priority group for this research area: they are vulnerable to tobacco industry promotions via cigarette packs and have a high risk of becoming addicted smokers, yet they are a sorely under-researched group. My training will help me design and execute behavioral research to address questions important to this tobacco control evidence base. The research component of this K07 complements my proposed training activities and will help to advance tobacco regulatory science by investigating the impact of warning message framing (gain- or loss-framed) and plain cigarette packaging for reducing the appeal of point-of-sale cigarette purchases (Aim 1) and the short-term prospective impact on smoking behaviors and motivation to quit (Aim 2), examining biobehavioral moderating and mediating mechanisms. Through prospective follow up, we will also assess the long-term durability of the impact of warning label message framing and plain packaging on smoking cessation to inform the development of a future R01 (Aim 3). By applying novel experimental methods, this study will generate data on the impact of cigarette packaging regulations on smoking behavior. This is a high priority research area for the NCI and the NIH collaborative Tobacco Regulatory Science Program. The experiences of this K07 will prepare me to pursue independent research focusing on behavioral tobacco control science and regulatory policy to prevent tobacco-associated cancers in the U.S.

Public Health Relevance

Smoking is the leading preventable cause of cancer death in the U.S., and young adult smokers are susceptible to the influence of tobacco industry marketing and have a high risk of becoming addicted, lifelong smokers. This study will examine whether cigarette packaging regulations including graphic health warning labels on cigarette packs and requiring plain, unbranded packaging reduce the appeal of cigarette purchases and prompt young adult smokers to quit. The results will help guide policies to regulate cigarette packaging as a way to reduce the number of cancer deaths that occur due to smoking in the U.S.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07CA172217-04
Application #
9330121
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Perkins, Susan N
Project Start
2014-09-01
Project End
2019-08-31
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Levy, David T; Yuan, Zhe; Luo, Yuying et al. (2018) Seven years of progress in tobacco control: an evaluation of the effect of nations meeting the highest level MPOWER measures between 2007 and 2014. Tob Control 27:50-57
Lipkus, Isaac M; Mays, Darren (2018) Comparing harm beliefs and risk perceptions among young adult waterpipe tobacco smokers and nonsmokers: Implications for cessation and prevention. Addict Behav Rep 7:103-110
Abudayyeh, Haneen S; Glasser, Allison M; Johnson, Amanda L et al. (2018) Social and substance use correlates of adult hookah use, 2016. Addict Behav 79:39-44
Mays, Darren; Villanti, Andrea; Niaura, Raymond S et al. (2017) The Effects of Varying Electronic Cigarette Warning Label Design Features On Attention, Recall, and Product Perceptions Among Young Adults. Health Commun :1-8
Mays, Darren; Hawkins, Kirsten B; Bredfeldt, Christine et al. (2017) The effects of framed messages for engaging adolescents with online smoking prevention interventions. Transl Behav Med 7:196-203
Lipkus, Isaac M; Mays, Darren; P Tercyak, Kenneth (2017) Characterizing Young Adults' Susceptibility to Waterpipe Tobacco Use and Their Reactions to Messages About Product Harms and Addictiveness. Nicotine Tob Res 19:1216-1223
Mercincavage, Melissa; Saddleson, Megan L; Gup, Emily et al. (2017) Reduced nicotine content cigarette advertising: How false beliefs and subjective ratings affect smoking behavior. Drug Alcohol Depend 173:99-106
Kraemer, John D; Strasser, Andrew A; Lindblom, Eric N et al. (2017) Crowdsourced data collection for public health: A comparison with nationally representative, population tobacco use data. Prev Med 102:93-99
Levy, David T; Mays, Darren; Yuan, Zhe et al. (2017) Public health benefits from pictorial health warnings on US cigarette packs: a SimSmoke simulation. Tob Control 26:649-655
Czoli, Christine D; Fong, Geoffrey T; Mays, Darren et al. (2017) How do consumers perceive differences in risk across nicotine products? A review of relative risk perceptions across smokeless tobacco, e-cigarettes, nicotine replacement therapy and combustible cigarettes. Tob Control 26:e49-e58

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