This application proposes Andrew Leuchter, M.D., as a candidate for the Geriatric Mental Health Academic Award, to conduct his research and teaching activities at UCLA. There are five aims in this application: 1) to foster Dr. Leuchter's development as an investigator in geriatric psychiatry; 2) to facilitate the development at UCLA of research aimed at improved methods for diagnosis and assessment of demented patients; 3) to broaden involvement by faculty in psychiatry and other departments at UCLA in geriatric mental health research; 4) to enable Dr. Leuchter to train other researchers to utilize his skills and methods; and, 5) to disseminate his research findings to other academicians at UCLA.
These aims will be achieved through a five-part plan. First, Dr. Leuchter will conduct two studies during the term of his award: a) a study aimed at the development of computer-analyzed electroencephalography (CEEG) as a test for the differential diagnosis of dementia, and b) a study of psychological, social, and biological factors that may contribute to depression in patients with dementia of the Alzheimer type (DAT). Second, he will pursue a program of structured academic courses and tutorials aimed at the development of his research skills. This program will include the study of biostatistics, clinical epidemiology, and electrophysiology. Third, as a member of the faculty, he will supervise residents on the geropsychiatry service, serve as an attending in two clinics where elderly psychiatric patients are seen, and train research fellows under the auspices of two NIMH training grants. Fourth, he will enhance his clinical skills by performing clinical and research evaluations on patients in the UCLA Geropsychiatry Clinic and the West Los Angeles VA (WLA-VA) Dementia Clinic. Fifth, he will participate as an instructor in seminars, case conferences, grand rounds, and other didactic programs of the UCLA and WLA-VA Hospitals as a means of disseminating his research findings throughout the academic setting. He also will be available as a consultant to other researchers in the institution.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07MH000665-02
Application #
3077730
Study Section
(LCRB)
Project Start
1986-08-01
Project End
1989-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Holschneider, D P; Leuchter, A F (1995) Beta activity in aging and dementia. Brain Topogr 8:169-80
Dunkin, J J; Osato, S; Leuchter, A F (1995) Relationships between EEG coherence and neuropsychological tests in dementia. Clin Electroencephalogr 26:47-59
Dunkin, J J; Leuchter, A F; Newton, T F et al. (1994) Reduced EEG coherence in dementia: state or trait marker? Biol Psychiatry 35:870-9
Leuchter, A F; Daly, K A; Rosenberg-Thompson, S et al. (1993) Prevalence and significance of electroencephalographic abnormalities in patients with suspected organic mental syndromes. J Am Geriatr Soc 41:605-11
Leuchter, A F; Cook, I A; Newton, T F et al. (1993) Regional differences in brain electrical activity in dementia: use of spectral power and spectral ratio measures. Electroencephalogr Clin Neurophysiol 87:385-93
Leuchter, A F; Newton, T F; Cook, I A et al. (1992) Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia. Brain 115 ( Pt 5):1543-61
Leuchter, A F; Read, S L; Shapira, J et al. (1991) Stable bimodal response to cholinomimetic drugs in Alzheimer's disease. Brain mapping correlates. Neuropsychopharmacology 4:165-73
Leuchter, A F; Walter, D O (1989) Diagnosis and assessment of dementia using functional brain imaging. Int Psychogeriatr 1:63-72
Leuchter, A F; Spar, J E; Walter, D O et al. (1987) Electroencephalographic spectra and coherence in the diagnosis of Alzheimer's-type and multi-infarct dementia. A pilot study. Arch Gen Psychiatry 44:993-8