The awardee has initiated a double-blind placebo controlled crossover study of the safety and efficacy of haloperidol in hospitalized schizophrenic children. During the Award period she also received an NIH Biomedical Research Support Grant and began an ongoing study of homovanillic acid, related to the Academic Award study. She has made presentations of her preliminary research findings at national meetings and at the local child psychiatry grand rounds. The goals for 2 more years of Award support are: (1) to continue the haloperidol study, enrolling 12 additional subjects, for a total of 32 in 5 years; (2) to begin, within the existing protocol, 2 new studies, of thought disorder and plasma haloperidol levels; and (3) to participate in a newly devised individualized training program, with ongoing supervision by Dr. Campbell and by two additional preceptors, Dr. Arnold J. Friedhoff and Dr. Murray Alpert.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Academic/Teacher Award (ATA) (K07)
Project #
2K07MH000763-04A1
Application #
3077754
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Project Start
1989-02-01
Project End
1994-06-30
Budget Start
1992-09-30
Budget End
1993-06-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Spencer, E K; Campbell, M (1994) Children with schizophrenia: diagnosis, phenomenology, and pharmacotherapy. Schizophr Bull 20:713-25
Spencer, E K; Alpert, M; Pouget, E R (1994) Scales for the assessment of neuroleptic response in schizophrenic children: specific measures derived from the CPRS. Psychopharmacol Bull 30:199-202
Spencer, E K; Kafantaris, V; Padron-Gayol, M V et al. (1992) Haloperidol in schizophrenic children: early findings from a study in progress. Psychopharmacol Bull 28:183-6
Spencer, E K; Campbell, M; Adams, P et al. (1990) Saliva and serum lithium monitoring in hospitalized children. Psychopharmacol Bull 26:239-43
Campbell, M; Locascio, J J; Choroco, M C et al. (1990) Stereotypies and tardive dyskinesia: abnormal movements in autistic children. Psychopharmacol Bull 26:260-6