Hypoxic brain injury is the most important neurological problem during the perinatal period. However, lack of information on cerebral blood flow (CBF) and its regulation in the postnatal period has prevented clear understanding of the pathogenesis of this condition. The overall goal of this proposal is to gain insight into the metabolic regulation of CBF in the postnatal period and to define the role of adenosine in linking brain metabolism and CBF at this developmental stage.
Our specific aims are 1) to investigate whether exogenous adenosine produces cerebral vasodilation and increase in CBF in the newborn; 2) to examine the role of adenosine in vasodilatory response to photic stimulation in the neonatal brain; 3) to determine if the adenosine level rises to produce vasodilation in the neonatal brain during hypoxia: 4) to determine the effect of systemic hypotension on the regional brain adenosine level and the role of adenosine in selective sparing of gray matter flow during severe systemic hypotension in the newborn. CBF will be measured by the radioactive microsphere technique. The brain dialysis technique will be employed in detecting the regional adenosine level. Adenine nucleosides and nucleotides will be measured by HPLC techniques.
|Gidday, J M; Park, T S (1992) Effect of 2-chloroadenosine on cerebrovascular reactivity to hypercapnia in newborn pig. J Cereb Blood Flow Metab 12:656-63|
|Park, T S; Gidday, J M; Gonzales, E (1991) Local cerebral blood flow response to locally infused 2-chloroadenosine during hypotension in piglets. Brain Res Dev Brain Res 61:73-7|
|Park, T S; Gidday, J M (1990) Effect of dipyridamole on cerebral extracellular adenosine level in vivo. J Cereb Blood Flow Metab 10:424-7|
|Park, T S; Cail, W S; Broaddus, W C et al. (1989) Lumboperitoneal shunt combined with myelotomy for treatment of syringohydromyelia. J Neurosurg 70:721-7|
|Park, T S; Broaddus, W C; Harris, M et al. (1989) Vacuum-stiffened beanbag for cranial remodeling procedures in modified prone position. Technical note. J Neurosurg 71:623-5|
|Park, T S; Van Wylen, D G; Rubio, R et al. (1988) Brain interstitial adenosine and sagittal sinus blood flow during systemic hypotension in piglet. J Cereb Blood Flow Metab 8:822-8|
|Park, T S; Van Wylen, D G; Rubio, R et al. (1987) Increased brain interstitial fluid adenosine concentration during hypoxia in newborn piglet. J Cereb Blood Flow Metab 7:178-83|
|Park, T S; Van Wylen, D G; Rubio, R et al. (1987) Interstitial fluid adenosine and sagittal sinus blood flow during bicuculline-seizures in newborn piglets. J Cereb Blood Flow Metab 7:633-9|
|Delashaw, J B; Park, T S; Cail, W M et al. (1987) Cervical meningocele and associated spinal anomalies. Childs Nerv Syst 3:165-9|
|Delashaw, J B; Persing, J A; Park, T S et al. (1986) Surgical approaches for the correction of metopic synostosis. Neurosurgery 19:228-34|
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