Abstract

Multi-infarct dementia (MID), the second major cause of dementia among the elderly, is a growing health problem. Although much has been learned about the pathophysiology of this disease, little is known about the etiological factors. We propose to seek information about epidemiologic, medical, stroke-specific and other clinical factors by carrying out a case-control study among stroke patients who do or do not develop MID. We will utilize epidemiologic interview together with psychologic testing, medical records, physical examination, psychiatric interview, and cranial computed tomography in 60 index cases and 120 control subjects to gather data about risk factors for dementia in stroke patients. Longitudinal study will be carried out to determine morbidity, mortality and outcome of cognitive impairment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG000350-02
Application #
3078548
Study Section
Aging Review Committee (AGE)
Project Start
1987-08-01
Project End
1990-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Michael Reese Hosp & Medical Center (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60616

  Publications

Gorelick, P B; Brody, J; Cohen, D et al. (1993) Risk factors for dementia associated with multiple cerebral infarcts. A case-control analysis in predominantly African-American hospital-based patients. Arch Neurol 50:714-20
Gorelick, P B; Chatterjee, A; Patel, D et al. (1992) Cranial computed tomographic observations in multi-infarct dementia. A controlled study. Stroke 23:804-11
Dollear, W; Gorelick, P B; Harris, Y et al. (1992) Vascular dementia: a clinical and death certificate study. Neuroepidemiology 11:53-8
Kittner, S J; Gorelick, P B (1992) Antiphospholipid antibodies and stroke: an epidemiological perspective. Stroke 23:I19-22
Gorelick, P B; Mangone, C A (1991) Vascular dementias in the elderly. Clin Geriatr Med 7:599-615
Gorelick, P B; Roman, G C (1991) Vascular dementia: in search of answers. Neuroepidemiology 10:225-7
Gorelick, P B; Bozzola, F G (1991) Alzheimer's disease. Clues to the cause. Postgrad Med 89:231-2, 237-8, 240
Gorelick, P B; Hier, D B; Mangone, C et al. (1991) Status of aluminum as a risk factor for dialysis encephalopathy and Alzheimer's disease. Int J Artif Organs 14:70-3
Mangone, C A; Hier, D B; Gorelick, P B et al. (1991) Impaired insight in Alzheimer's disease. J Geriatr Psychiatry Neurol 4:189-93
Hier, D B; Mangone, C A; Ganellen, R et al. (1991) Quantitative measurement of delta activity in Alzheimer's disease. Clin Electroencephalogr 22:178-82

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