The proposed research is designed to determine the prevalence and incidence of urinary incontinence by type (urge, stress and mixed), frequency and severity; to determine risk factors for urinary incontinence; to test the effectiveness of hormone therapy to decrease risk for developing urinary incontinence; and to improve the severity of urinary incontinence in elderly women.
The research aims will be achieved b analyzing data from an established study of osteoporotic fractures (SOF) and from an established heart and estrogen-progestin replacement study (HERS). The former (SOF) is a prospective cohort study of risk factors for osteoporotic fractures among 9704 women 65 years of age or older, while the latter (HERS) is a randomized trial of hormone therapy to prevent recurrent heart disease events in 2763 postmenopausal women with heart disease. Both provide measures of incontinence that will allow calculation of prevalence and information on a large number of potential risk factors including age, reproductive history, obesity, medical illnesses, medications, social habits, and physical performance. Identifications of risk factors will guide the development of randomized trials of the efficacy of preventable or modifiable factors. Ancillary measurements appended to these studies will provide data on incidence of incontinence. As a large randomized trial, HERS will provide definitive data on the efficacy of hormone therapy to prevent the development or urinary incontinence and as treatment for incontinence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG000710-04
Application #
6168627
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Slater, Stanley L
Project Start
1997-05-01
Project End
2001-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
4
Fiscal Year
2000
Total Cost
$85,018
Indirect Cost
Name
University of California San Francisco
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Phelan, Suzanne; Grodstein, Francine; Brown, Jeanette S (2009) Clinical research in diabetes and urinary incontinence: what we know and need to know. J Urol 182:S14-7
Brown, Jeanette S; McNaughton, Kristin S; Wyman, Jean F et al. (2003) Measurement characteristics of a voiding diary for use by men and women with overactive bladder. Urology 61:802-9
Larkin, Lisa M; Kuzon, William M; Halter, Jeffrey B (2003) Effects of age and nerve-repair grafts on reinnervation and fiber type distribution of rat medial gastrocnemius muscles. Mech Ageing Dev 124:653-61
Brown, Jeanette S; Waetjen, L Elaine; Subak, Leslee L et al. (2002) Pelvic organ prolapse surgery in the United States, 1997. Am J Obstet Gynecol 186:712-6
Wilson, L; Brown, J S; Shin, G P et al. (2001) Annual direct cost of urinary incontinence. Obstet Gynecol 98:398-406
Subak, L L; Waetjen, L E; van den Eeden, S et al. (2001) Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol 98:646-51
Brown, J S; Vittinghoff, E; Kanaya, A M et al. (2001) Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factors. Obstet Gynecol 98:1045-52
Brown, J S; Sawaya, G; Thom, D H et al. (2000) Hysterectomy and urinary incontinence: a systematic review. Lancet 356:535-9
Reynolds 4th, T H; Brozinick Jr, J T; Larkin, L M et al. (2000) Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training. J Appl Physiol 88:2240-5
Feely, R S; Larkin, L M; Halter, J B et al. (2000) Chemical versus dual energy x-ray absorptiometry for detecting age-associated body compositional changes in male rats. Exp Gerontol 35:417-27

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