Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
7K08AG000798-02
Application #
2881936
Study Section
National Institute on Aging Initial Review Group (NIA)
Project Start
1998-02-15
Project End
2003-01-31
Budget Start
1998-12-01
Budget End
1999-01-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Neurology
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Simon, David K; Lin, Michael T; Zheng, Leiya et al. (2004) Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiol Aging 25:71-81
Gajewski, Carl D; Lin, Michael T; Cudkowicz, Merit E et al. (2003) Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells. Exp Neurol 179:229-35
Vives-Bauza, Cristofol; Andreu, Antoni L; Manfredi, Giovanni et al. (2002) Sequence analysis of the entire mitochondrial genome in Parkinson's disease. Biochem Biophys Res Commun 290:1593-601
Lin, Michael T; Simon, David K; Ahn, Colette H et al. (2002) High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet 11:133-45
Simon, D K; Lin, M T; Ahn, C H et al. (2001) Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics 73:113-6
Miller, F D; Geddes, J W (1990) Increased expression of the major embryonic alpha-tubulin mRNA, T alpha 1, during neuronal regeneration, sprouting, and in Alzheimer's disease. Prog Brain Res 86:321-30